Director/Senior Director Jobs

About Aeglea

In June 2023, Aeglea completed the asset acquisition of Spyre and shifted its disease focus to IBD. Aeglea is advancing a pipeline of antibody therapeutics with the potential to transform the treatment of IBD. The approaches combine novel antibody engineering, rational therapeutic combinations, and precision immunology approaches to maximize efficacy, safety, and convenience of treatments for IBD. The company's two parallel lead programs—SPY001 and SPY002—target ɑ4β7 and TL1A, respectively, and build upon the validation of these targets by existing commercial- and clinical-stage antibody therapeutics. The company’s lead programs are projected to enter clinical studies in 2024.

On June 22, 2023, we completed a $210 million private placement of our Series A Preferred Stock with a syndicate of healthcare investors led by Fairmount Funds Management LLC, with participation from Fidelity Management & Research Company, Venrock Healthcare Capital Partners, Commodore Capital, Deep Track Capital, Perceptive Advisors, RTW Investments, Cormorant Asset Management, Driehaus Capital Management, Ecor1 Capital, RA Capital Management, Surveyor Capital (a Citadel company), and Wellington Management Company LLP, as well as additional institutional investors.

Role Summary

The Director/Senior Director will be responsible for multiple aspects of drug development, broadly defined, across Spyre’s pipeline and have an opportunity to serve as the nonclinical lead on certain development programs. This individual will be a key member of the team driving execution of a broad array of studies designed to evaluate/characterize therapeutic antibodies, select development candidates, and support development of Spyre pipeline programs. Substantial effort will be spent designing and directing studies at CROs, characterizing the biochemical/cell biological properties of therapeutic antibodies, and capturing the design and results of key studies in a variety of written reports or other documents. This role will report to the SVP of Preclinical Research and Development and collaborate closely with other functional areas within Spyre (Operations, Regulatory, Clinical, etc.).

Key Responsibilities

• Work closely with project management, outside consultants, and other stakeholders to execute nonclinical development activities according to program needs.
• Serve as nonclinical representative on a multidisciplinary team of R&D professionals to progress therapeutic molecules from lead optimization through late-stage development.
• Communicate plans, progress, and results of key studies to internal and external audiences via written and verbal means.
• Contribute to the design, execution, and interpretation of studies aimed at characterizing therapeutic antibodies in accordance with relevant regulatory requirements including review of literature and assessment of compliance.
• Travel to and scientifically evaluate vendors/CROs for the purpose of conducting a variety of studies related to development activities.
• Oversee CROs executing studies related to pharmacology, bioanalysis, immunogenicity, animal models of disease, safety studies including GLP toxicity, and other development activities.
• Act as study monitor or identify a suitable study monitor when conducting GLP studies.

Ideal Candidate

• Availability to participate in calls across multiple international time zones.
• Ability to multi-task and keep pace with a fast-moving organization.
• Experience with CRO engagement as well as regulatory filing preparation and messaging.
• Excellent communication skills with an ability to present to a variety of stakeholders and adjust message for maximum understanding of all parties.
• Strong leadership mentality, willing to learn from others, and dedication to being an excellent colleague within Spyre and with our key partners.
• 3+ years of drug discovery and/or drug development experience with complex biologics spanning early and late-stage development, including IND-enabling studies and IND filings.
• PhD in relevant discipline (e.g., pharmacology, immunology, or another relevant field)
• Ability and willingness to travel occasionally in support of team objectives and goals.

What We Offer

• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
• Commitment to provide professional development opportunities.
• Two, one-week company-wide shutdowns each year.
• Remote working environment with frequent in-person meetings to address complex problems and build relationships.
• Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
• Flexible PTO