Senior Scientist, Molecular Pharmaceutics

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies that matter most. You will apply your skills to accelerate and bring the best-in-class small molecule medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. Your creativity in developing new ideas will be used frequently. You will undertake mentoring activities to guide other team members.

The key purpose of this position is to support and influence the early candidate substrate from a physical chemical, drug delivery and bioperformance perspective through close collaboration with partners on the Research Project Teams and in Pharmaceutical Science. You will need to act as a pharmaceutical science subject matter expert to inform, educate and influence Discovery teams in finding NCEs with desirable drug delivery and performance properties. This role will include assessment of in silico, in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies. An awareness of later stage development needs as well as an understanding of the disease state and biology will help to enable the definition of the required design elements.

This position will interface with multidisciplinary teams and work closely with colleagues in Medicinal Chemistry, Biology, Drug Safety and Pharmacokinetics Dynamics & Metabolism. Strong relationships with Clinical, Analytical, Materials Science and late-stage clinical formulation colleagues are also expected.

It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Assess and clearly communicate drug delivery and performance risks (using in silico, in vitro and in vivo data as well as sound scientific principles)
• Ensure own work, meets agreed project deliverables and stakeholder needs, maintaining quality and reporting findings either verbally or in written format
• Identify opportunities to use computational tools to help solve project challenges.
• Participate on Pharmaceutical Sciences teams in the development of novel small molecule drug products.
• Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the physics and physical chemistry of the solution sate thermodynamics for organic compounds.
• Closely collaborate with Research partners to evaluate molecular attributes relevant to drug delivery and influence team strategies.
• Publish research in reputed scientific journals and give presentations at national and international conferences.
• Design and develop fit for purpose preclinical formulations (traditional and enabling) to enable robust candidate selection and progression.
• Act as a technical and scientific resource within own project team/ discipline.
• Interface with multi-disciplinary teams composed of scientists with experience and expertise in biology, pharmacology, synthetic organic chemistry, chemical engineering, material science, etc.
• Participate on multidisciplinary project teams and collaborate with colleagues to reach project milestones and project timelines.
• Develop hypotheses, design experiments to test hypothesis and provide interpretation of data to assist in resolving challenging physicochemical problems associated with drug delivery systems.
• Apply technical and functional knowledge to design experiments, and independently completes work within own work group/ project team, working on multiple subprojects in parallel.

Qualifications

• Master’s degree (MA/MS) and 7+ years of relevant experience or Doctoral Degree (PhD, MD, PharmD) in Pharmaceutics, Chemistry, Medicinal Chemistry, Physical Chemistry or Biophysics
• Demonstration of strong scientific leadership and curation and execution of new technology initiatives is desired.
• Skills with working in research teams at interfaces and in multi-disciplinary environments is beneficial.
• Excellent organizational and interpersonal skills.
• Knowledge of data structure, capture, analysis and visualization is desired; experience with Spotfire or Tableau would be beneficial.
• Application and use of fundamental principles to solve complex drug delivery and formulation problems.
• Excellent written and verbal communication skills.

Physical/Mental Requirements

Candidates must have the ability to perform laboratory work.

Non-standard Work Schedule, Travel Or Environment Requirements

Occasional travel to other Pfizer sites such as Groton, CT will be required.

Relocation support available

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development