Scientist, - In Vitro Antibody Discovery

At Sanofi we are committed in our quest to be a world-class biologics research organization and are steadfast in our goal to bring next generation, transformative therapies to patients. Our global Large Molecule Research (LRM) platform consists of five sites, and approximately 550 personnel focused on antibodies, nanobodies and synthorins as therapeutic modalities. Our platform enables and partners closely with other research platforms and Sanofi’s therapeutic areas (Immunology, Oncology, Rare Disease and Neurology) in the discovery and ultimate delivery of new candidate molecules into our pipeline.
To continue to build on our success in these efforts we are seeking an experienced, versatile, and self-driven individual to join the Antibody Discovery group at our US Boston site. This position will play a critical role in shaping lead discovery efforts of next generation biotherapeutics in Immunology and IO therapeutic areas, with strong focus on multi-specific modalities. The successful candidate will have demonstrated in-depth understanding of in vitro display (i.e., mammalian, phage or yeast) methodologies, antibody discovery workflows, protein engineering, sequence analysis and excel in a fast-paced environment. The candidate will be responsible for advanced lab activities, project leadership and is expected to impact at the organizational level in a matrix team environment.
This is an exciting opportunity to join a group of accomplished scientists focused on the design and realization of advanced therapeutic modalities, including multi-specific antibodies such as those that have recently entered the clinic.
Responsibilities

• Effectively manage projects and resources to maximize progress.
• Manage several projects simultaneously and act as point of accountability for in vitro display efforts on projects.
• Analyze and present data, both in written reports and oral presentations.
• Analyze antibody NGS data and apply AI/ML techniques to de novo antibody discovery and sequence optimization.
• Apply rational antibody engineering techniques to modify pharmacological activity, developability, confer pH dependent binding, etc
• Work collaboratively with other antibody discovery teams, locally and globally.
• HT recombinant expression of antibodies using cell-free systems and their application to biochemical assays (ELISA, flow cytometry, etc.).
• Design and execute phage- and yeast-displayed antibody discovery campaigns using synthetic, naïve and immunized repertoires.
• Attend and present at scientific conferences.
• Initiate and manage external academic collaborations in the antibody discovery and engineering space.
• Bring new ideas for scientific innovation / technology development and champion them to proof-of-concept studies.
• Act as a biologics core project team member to provide technical guidance and leadership to pre-clinical project teams.

Qualifications

• Sound understanding and record of accomplishment in antibody engineering.
• Highly analytical mind, attention to detail, and organizational skills are critical.
• Experience with library construction, NGS/deep mining, multi-specific modalities, alternative antibody scaffolds and engineering is highly preferred.
• Ability to work independently to design and trouble-shoot experiments.
• Hands-on experience with antibody phage/yeast display, HT screening, flow cytometry and kinetic analysis is required.
• Familiarity with in vitro immunization platforms (e.g. human immune organoids) is a plus.
• Self-starter with a strong sense of responsibility, integrity, and a collaborative spirit.
• PhD in Biochemistry, Molecular or Structural Biology or a closely related field + 3 years of relevant experience in academic or biopharmaceutic setting or MS + 2 years of relevant experience or BS +6 years of relevant experience, with robust track record of peer-reviewed publications, patents and meeting presentations.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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