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Research Associate Scientist, In Vivo- Oncology Drug Discovery Unit
Company | BioSpace |
Address | Boston, MA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Internet News |
Expires | 2023-08-01 |
Posted at | 10 months ago |
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
- Develop animal models to test the biological efficacy of therapeutic agents for oncology indications
- Identify, plan, and execute well defined scientific projects and communicates program strategy and timelines to management.
- Design and implement in vivo efficacy models in xenograft and PDX models
- Identify experimental protocols and in vivo models
- Maintain laboratory notebooks and follow laboratory practices in compliance
- Interpret results of complex experiments
- Help with external collaborations with CROs and and establish new protocols
- Execute experiments with minimal supervision and deliver comprehensive high quality data sets to help decision-making
- Prepare and present comprehensive technical or project reports and formal presentations
- Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
- Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models
- Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture is important.
- Experience in molecular biology and biochemical techniques such as western blot, molecular cloning is a plus.
- Hands –on basic experience with multi-color flow cytometry, molecular biology techniques (PCR, Gibson assembly, cloning etc), ELISA, MSD and other standard cell-based and non-cell based biochemical assays.
- Knowledge in immunology or immune oncology. Understanding of cell and gene therapies.
- Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, IT, PO), and blood/tissue collection. Imaging experience is highly desirable.
- Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc)
- Experience with biologics is prefered (Antibodies, ADCs, Cell therapeis etc)
- MS in a scientific discipline (or equivalent) with 3+ years relevant industry experience, or BS in a scientific discipline with 5+ years experience, or Associates degree in scientific discipline with 7+ years relevant industry experience
- Flexible Work Paths
- Comprehensive Healthcare: Medical, Dental, and Vision
- Community Outreach Programs and company match of charitable contributions
- Health & Wellness programs including onsite flu shots and health screenings
- Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
- Family Planning Support
- Generous time off for vacation and the option to purchase additional vacation days
- Tuition reimbursement
-
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