Research Scientist Ii: Cell Engager Therapies: Invitro/Exvivo Cell And Functional Biology

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Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
OBJECTIVES/PURPOSE
The Cell Engager team of the Oncology DDU is seeking a highly motivated Research Scientist II with demonstrated skills in interrogating immune and tumor cell function both in vitro and exvivo to discover and develop novel therapeutics that mobilize the immune system against cancer. As a key member of the team, the candidate will be responsible for assessing therapeutic concepts and immune engager molecules and advancing novel research molecues towards development candidates and IND. The position is hands-on and requires effective communication and documentation of results and collaboration with key stakeholders in ODDU (IOI, C2H), Global Biologics, DSRE, DMPK, Translational teams. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.
Accountabilities

• Evaluate the dual antigen targeting strategies in Immunotherapies as part of novel COBRA design
• Contributes to new ideas and concept generation aligned with Cell Engager Strategy
• Utilize immune readouts such FACS based immunophenotyping, T cell activation assays, cytokine profiling that can aid with translational biomarker strategy
• Uses defined practices and theoretical knowledge to perform analysis, interpret results and determine appropriate action
• Support target validation efforts by characterizing receptor internalization kinetics by quantitative imaging technology
• Design, lead, execute T cell dependent cytotoxicity, cytokine release, mRNA profiling and other in vitro cell-based assays to support candidate lead selection process
• Identify state of the art experimental protocols and releavnat IO assays
• Interface with in vivo, Global biologics, DMPK,DSRE, and ITT groups to advance lead selection process build synergies across concepts
• Identifies, plans and executes well defined scientific projects
• May serve as a PTL over time
• Build relationships with external research collaborators and CROs for cell based and translational assays
• Will contribute to strategic discussions and goal setting with team
• Initiates investigation of new experimental approaches to specific problems using scientific theory and technical literature to fill key gaps in critical path
• Design and execute in vitro and ex vivo functional assays to assess therapeutic concepts aligned with principles of the COBRA and othe CE platorms
• Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
• Maintain laboratory notebooks and keep in compliance with Takeda policies
• Prepares and presents comprehensive technical or project reports and formal presentations / posters to full range of internal/external audiences
• Interprets results of complex experiments
• Executes experiments with minimum supervision and delivers comprehensive high quality data sets to enable decision making
• Establish and validate next generation 3D tumor organoid models for ex vivo preclinical assessments
• Work in close collaboration with translational team to employ fluorescent-based phenotyping of immune cells in tumor FFPE tissue sections for ex vivo assessments

DIMENSIONS AND ASPECTS
Technical/Functional (Line) Expertise

• Indepently investigates new immunological techniques, that can be applied to team projects
• Able to clarify requests and provide suggestions and put data into context especially in context of assay design and quality of data
• Expected to participate in new target identification / validation process
• Demonstrates in-depth technical knowledge within various assay development platforms
• Demonstrates theoretical knowledge of cell engager platforms
• Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology
• Serves as the in vtro immunobiology lead on projects provinding key scientific feedback to advance programs in a matrixed environment.
• Scientifically independent
• Conducts scientific presentations to internal audiences
• Strives towards expanding scientific knowledge in immunology
• Participates in and supervises external interactions and collaborations with companies and academic research groups and potential collaborator
• Provides information to project teams to influence direction, align with departmental goals and/or business
• Independently manages own workload
• Keeps current with emerging trends in immne cell engagers for application in cancer therapy
• Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence; may manage interns

Education, Behavioural Competencies And Skills

• Hands –on experience and ability to work with minimum supervision in carrying out high throughput data acquisition, analysis, storage and reporting by FACS CANTO, Tyto, FACS ARIA, ELISA, Luminex, MSD, IncuCyte, Nanolive and other flow based cytokine assays is requiredExperience in the design and construction of mammalian expression vectors and cell transfection and/or viral-mediated cell transduction, preferably of primary immune cells is a must
• Excellent team player with a can-do attitude with an ability to thrive in a dynamic “biotech- like” environment and work in cross-functional project teams
• PhD in Immunology, Cell Biology and/ or Biochemistry, or MS with 6+ years experience (industry experience preferred), or BS +8 years in Immunology, Cell Biology, Pharmacology.
• Experience with
• Ability to run, nanostring, qPCR assays and analysis is required
• Experience with flourescence imaging is desired
• Experience with mammalian cell culture with best practices in tissue culture including primary human cells and tissues is strongly is required
• Innovative and critical thinking
• Self-motivated, collaborative with excellent time management and organizational skills
• Experience with ex vivo tumoroid/organoid cultures is required
• Excellent written and verbal communication skills,
• Experience with cell engineering and gene-editing is prefered
• Extensive hands-on experience and knowledge in a wide range of immunological assays using cell lines and primary immune cells including T cells, NK cells, Macrophages and dendritic cells to design new approaches for immune engaging mechanisms with a focus on biologics discovery and development is expected.
• Experience with biologics is a must (Antibodies, ADCs, Cell therapeis etc)
• Use of scientific databases and application for data management and data analysis

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
What Takeda Can Offer You

• Community Outreach Programs
• Tuition reimbursement Company match of charitable contributions
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• 401(k) with company match and Annual Retirement Contribution Plan

Base Salary Range 130,200.00 to 186,000.00 Employees may also be eligible for Short Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.
The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.
Empowering Our People to Shine
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EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time