Head Of Enterprise It Systems

Company Profile
Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit www.vaxcyte.com.
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte’s PCV franchise, consisting of VAX-24 and VAX-31, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.
Summary
The Head of Enterprise IT Systems is accountable for the breadth of Vaxcyte’s IT-managed, enterprise system portfolio. For this position the term “enterprise” encompasses platforms, systems, tools and supporting technologies that benefit the broader Vaxcyte user population. This position actively partners and collaborates with business leaders to derive and drive value from existing and new technology investments, including forward-thinking integration, automation and analytical capabilities. Vaxcyte’s IT system landscape is, and will continue to be, nearly 100% multi-tenant cloud. As such, optimizing and coordinating internal and external talent across operational and project teams is essential. This is an exciting and engaging role that works with nearly every business function. This is a hands-on role that reports to the Vice President of IT and Facilities at Vaxcyte’s San Carlos, California headquarters.
Essential Functions

• Provide expert hands-on design and configuration assistance.
• Harden system security through best-practice authentication, monitoring, and employee training.
• Work closely with IT leadership and business partners to evolve our IT strategic roadmap.
• Optimize system support structures to ensure a high level of end user satisfaction.
• Transition appropriate levels of our current enterprise system ownership into IT.
• Own budget forecast, management and actuals tracking for in-scope technology spend.
• Help establish, maintain, and deliver against IT’s Computer System Assurance (CSA) toolkit.
• Establish and nurture close, cross-functional business partnerships.
• Ensure system and operational compliance across regulatory needs (SOX, GxP, Privacy, etc.).
• Deliver strategic roadmap initiatives with a cloud-first, always-on and access-anywhere mentality.
• Coach team on technical and procedural best-practices along with a customer-first attitude.
• Partner with and manage 3rd party vendors for project delivery and operational managed services.
• Closely manage and optimize license procurement and provisioning.
• Establish and/or help facilitate appropriate Change Review Boards.
• Help develop data transfer agreements and technology solutions with 3rd party partners.
• Help build enterprise competency centers that span in-scope systems and technologies.
• Lead and/or coordinate Managed Services and internal techno-functional resources.
• Serve as IT Subject Matter Expert for regulatory audits as needed.
• Grow internal IT team commensurate with business and technology needs.

Requirements

• IT (SSO, SOA, Workflow Automation, Analytics, Cybersecurity)
• Regulatory (Submissions)
• Adaptable and flexible; adapt to changing business needs, conditions, and priorities.
• Quality (eDMS, eQMS, LMS)
• Bachelor’s degree in IT or related discipline.
• O G&A (Procurement, Punchout, Close Automation, Time Tracking, Contracts, HRIS)
• All Vaxcyte employees require vaccination against COVID-19.
• Thrive in a fast-paced, results-driven, and team-oriented environment.
• 5+ years in managerial role that required hiring, leading, and developing IT employees.
• Hands-on experience with NetSuite and Veeva platforms required.
• Hands-on knowledge in applying risk-based software validation methods (i.e., GAMP5).
• 10+ years IT experience with a minimum of 5 years in the Life Sciences industry.
• Working knowledge of regulatory requirements including SOX, GxP, HIPAA and GDPR.
• Working functional and systems experience across:
• Proven PM and operational experience delivering and maintaining enterprise IT systems.
• Clinical (CTMS, eTMF)
• Exceptional interpersonal and consultative skills are an absolute must.
• Accountable and dependable; take personal responsibility for the quality and timeliness of work.

Reports to: Vice President, IT & Facilities
Location: San Carlos, CA
Compensation
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $253,000 - $270,000