Research Associate Scientist :Io Biology_In Vitro And Exvivo

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Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
OBJECTIVES/PURPOSE
The Cell Engager team of Takeda's Oncology Drug Discovery Unit is looking for an in vivo lab-based scientist to join a collaborative and dynamic team. Contribute to pre-clinical projects by developing well-defined mechanistic experiments and projects within oncology research. The candidate should have a foundation in immunology and/or cancer biology with proven skills in molecular biology and in vitro/exvivo assays in oncology drug discovery reserach. The candidate will play a critical role in supporting key pipeline programs tied to Gamma Delta concepts as well as other immune engaging mechanisms. The position will require the individual to be hands-on. The individual will collaborate and demonstrate effective communication and documentation of results with key stakeholders in the ODDU (IOI, C2H) GB, DSRE, DMPK, Translational teams and CTI. Provides theoretical/conceptual input to the design, development and execution of well-defined projects within the area of expertise. The selected candidate will provide technical leadership for research project implementation and coordination.
Accountabilities

• Provides information to project teams to influence direction, align with departmental goals and/or business
• Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology
• Prepares and presents comprehensive technical or project reports and formal presentations
• Strives towards expanding scientific knowledge in immunology
• Provide scientific knowledge and expertise in antibody evaluation, gamma delta T cell biology and molecular biology.
• Drive assay development and implement new methods for a diverse range of immunology-focused and translational assays.
• Serves as the in vitro rep or lead on projects providing key scientific feedback to advance programs in a matrixed environment.
• Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence.
• Initiate investigation of new experimental approaches to specific problems using scientific theory, data from external partners, and technical literature
• Generate over-expressing cell lines via lentiviral transduction to study the target’s functional biology and run high throughput screening of target antibodies as needed
• Assist with external collaborations with CROs as needed
• Optimize, execute, and troubleshoot in vitro assays including flow cytometry-based experiments to test the binding of antibodies to various targets, functional assays to evaluate the activation or suppression of T cells in response to the antibodies, and reporter cell line-based assays for cell signaling.
• Demonstrates in-depth technical in vitro and gamma delta T cell biology knowledge
• Conducts scientific presentations to internal audiences
• Independently manages own workload
• Able to clarify requests and provide suggestions and put data into context especially in context of study design and quality of data
• Participate on cross functional project team meetings to provide key scientific insight
• Help with isolation of skin and blood derived VD1 cells working closely with CE and CTI team members
• Maintain laboratory notebooks and follow laboratory practices in compliance
• Contributes to IND report and documentation.
• Isolate, culture, and differentiate various immune cell populations (VD1 cells, MDSCs, T cells, monocytes, etc).
• Ability to multi-task effectively and prioritize workload
• Develop assays to identify new biology related to Vd1 engager MOA
• Analysis, interpretation, and presentation of data to important partners, and play an active role in the subsequent scientific discussions leading to important decisions and program-ensuring next steps
• Help with 2D/3D based assay systems to dissect cell cell interactions
• Help with external collaborations with CROs and establish new protocols

Education, Behavioural Competencies And Skills

• MS with 3+ years experience or BS with 5+ years experience with previous industry experience strongly preferred
• Excellent written and verbal communication skills,
• Excellent team player with a can-do attitude with an ability to thrive in a dynamic “biotech- like” environment and work in cross-functional project teams
• Hands –on experience with multi-color flow cytometry, ELISA, MSD and other standard cell based and non-cell based biochemical assays is required.
• Uses defined practices and theoretical knowledge to perform analysis, interpret results and determine appropriate action
• Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models is required.
• Identifies, plans and executes well defined scientific projects
• Interprets results of complex experiments
• Self-motivated, collaborative with excellent time management and organizational skills
• Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc)
• Initiates investigation of new experimental approaches to specific problems using scientific theory and technical literature
• Takeda’s high-engagement culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture
• Strong experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection. Cell culturing and maintaining human tumor cell lines and primary human cells with best practices in tissue culture is critical
• Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
• Innovative and critical thinking

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
What Takeda Can Offer You

• 401(k) with company match and Annual Retirement Contribution Plan
• Community Outreach Programs
• Generous time off for vacation and the option to purchase additional vacation days
• Health & Wellness programs including onsite flu shots and health screenings
• Tuition reimbursement Company match of charitable contributions

Base Salary Range 87,500.00 to 125,000.00. Employees may also be eligible for Short Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.
The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.
Empowering Our People to Shine
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EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time