In Vivo Biologist Jobs

Knowledge of in vivo pharmacology principles, drug metabolism and in vivo dosing and sampling skills

Demonstrated understanding and experience in performing pharmacological and mechanistic studies in in-vivo models of Retinal Diseases, including all pertinent ex-vivo analyses.

Expertise with integrated physiological assessments in the eye, including ocular dosing and dissection techniques. Experience in ocular imaging is a plus

Demonstrates good oral, written, and interpersonal skills and is a strong collaborator and team player.

Protocol development and approval in partnership with IVS and IACUC. Responsible for validity, reproducibility, interpretation, documentation.

Works under limited supervision with a high level of autonomy.

Certification or training in project management.

Assist in the preparation and submission of regulatory documentation. Resource Management:

Proven track record in project management and team leadership.

Manage budgets, resources, and timelines for in vivo projects.

Ph.D. in a relevant scientific field (e.g., biology, pharmacology) or equivalent experience.

Substantial experience in in vivo research, including experience with various animal models and techniques.

Excellent communication and collaboration skills with an ability to work both independently and in a team environment.

Critical thinking with high degree of innovative and analytical skills

Perform efficacy and tolerability testing in mouse cancer models

Independently document, analyze, and reporting of animal models (syngeneic and xenograft model, human PBMC model), pharmacokinetic (PK) and pharmacodynamic (PD) studies.

Work collaboratively with members of the discovery biology team and provide summaries to project teams.

Highly organized, motivated, and self-initiated, with ability to prioritize and solve challenges.

Education: Masters or PhD or equivalent experience in Neuroscience or relevant scientific disciplines with a strong emphasis on in vivo research.

Manage and analyze experimental data.

Seeking candidates with 2-6 years’ experience in industry ideally. 2+ years in drug discovery and neurodegenerative disease areas is highly desired.

Experience with models of neurodegenerative diseases, including molecular mechanisms involving innate repair pathways.

Extensive hands-on experience with animal handling and dosing techniques, including administration routes (e.g., oral, intravenous, subcutaneous) and sample collection methods.

Proficiency in laboratory bench skills such as RNA analysis, enzyme assays, kinetic analyses, microscopy, neuroanatomy and/or histology.

Can independently manage and troubleshoot small and large rodent studies for in vivo and ex vivo endpoints.

Experience with design, documentation, and execution of experiments

Scientific and team-directed communication skills

Experience on cross-functional therapeutic program teams

Experience within a start-up or small biotech environment

In vitro binding (such as Biacore, Octet) and activity assays

6+ years direct, hands-on in vivo experience (rodents) – Required

Experience with in vivo models of cancer – Required

Knowledge in immunoassay, such as Flow cytometry, ELISA, etc. – Highly preferred

Ability to manage multiple projects, and handle documents in a timely manner

Independently perform tumor implantation, mice randomization, group assignment and dosing via tail-IV, IP, SubQ and intramuscular injections

Independently monitor tumor progression by caliper measurement or IVIS imaging

Working knowledge of data management and statistical analysis (Graph Pad Prism, Office 365, etc);

Hands-on experience with small animal imaging modalities, i.e., bioluminescence (BLI) and/or nuclear imaging (PET/SPECT);

Working knowledge of fundamental molecular biology techniques applicable to ex vivo tissue analysis;

Detail-oriented, highly organized, with excellent oral and written communication skills; Holding high standard of scientific integrity;

Hands-on experience in orthotopic tumor modeling and aseptic surgery techniques (e.g., castration);

Experience in Mammalian cell culturing and maintaining human tumor cell lines and primary human cells;

Experience with additional ex vivo PD assessment assays (basic biochemical and immunological methods including cell culture, ELISA/multiplex assays)

Team player who is well organized with excellent interpersonal and oral/written communication skills and be able to perform multitasking as needed

Biotechnology or pharmaceutical industry experience preferred but not essential

Background knowledge of immunology is a plus but not required

Competitive Remuneration And Benefits Apply

Ability to independently design and execute research plans for one or more programs, and to review, analyze, and interpret experimental results

Identify, plan, and execute well defined scientific projects and communicates program strategy and timelines to management.

Knowledge in immunology or immune oncology. Understanding of cell and gene therapies.

Experience with biologics is prefered (Antibodies, ADCs, Cell therapeis etc)

Experience in molecular biology and biochemical techniques such as western blot, molecular cloning is a plus.

What Takeda Can Offer You

and Long-Term Incentive benefits. Employees are eligible to participate in

Executes, tracks, and manages genotyping.

Excellent oral and written communication skills.

Preferred - Experience with transcardiac perfusion.

Preferred - Experience characterizing rodent models of various human diseases with behavioral testing.

Preferred – Experience with survival and stereotactic surgeries.

Preferred - Previous industry experience.

Leverage and expand automated capabilities to perform suitable components of daily workflows.

Exhibit a can-do attitude with excellent interpersonal and communication skills to multiple teams across different functional areas

BS or MS in Biology or other closely related field with typically 0-3+ years of industry or academic experience

Knowledge of basic immunology concepts

Strong attention to quality and details when exercising organizational, documentation and interpersonal skills

Experience with mammalian cell culture, aseptic technique is highly desired

3+ years of relevant experience

Experience in a Good Laboratory Experience environment beneficial but not required

Responsible for performing, recording, and reporting data from in vivo studies, including tumor implantation, dosing, bleeds and terminal collections.

Luminescent and Fluorescent imaging of animals to determine drug distribution and monitor disseminated disease.

May be involved in downstream analysis of ex vivo samples.

Participate in preparation of study documentation.

3+ years of relevant experience

Experience in a Good Laboratory Experience environment beneficial but not required

Responsible for performing, recording, and reporting data from in vivo studies, including tumor implantation, dosing, bleeds and terminal collections.

Luminescent and Fluorescent imaging of animals to determine drug distribution and monitor disseminated disease.

May be involved in downstream analysis of ex vivo samples.

Participate in preparation of study documentation.

Develop in-house capabilities to support work performed at CROs.

Hands-on experience co-leading drug discovery projects from target validation to IND-enabling studies

Knowledge of preclinical and clinical biomarker discovery and development

Experience as a team member and/or leading multi-disciplinary teams focused on small molecule drug discovery

At home in a results-driven, highly accountable environment where you can make a clear impact

Strong communication and interpersonal skills.

● Hands-on experience with molecular biology methods including PCR, qPCR, DNA purification, SDS-PAGE, microcopy, and cloning

● Basic knowledge of laboratory practices and safety.

● Bench Level Laboratory experience

● Excellent communication, interpersonal, and organizational skills.

● Performing multicolor flow cytometry analysis

● Assess T cell cytokine profiles by ELISA or MSD

Participate in experimental design and planning, colony management, and breeding programs.

BS degree in biology, veterinary science, or a related field (or equivalent experience)

Experience breeding and maintaining rodent colonies

Experience managing and supporting a research lab

Certifications: ALAT, LAT, LATG and/or RVT

Surgical assisting and/or working knowledge of aseptic technique, rodent anesthesia/analgesia

Calculate and verify doses, demonstrating proficiency in a range of technical skills such as administration and necropsy

Experience in the CRO industry, managing high-volume, fast-paced client projects is a plus

Preferred certifications: ALAT, LAT, LATG

Over five years of related laboratory animal science experience, preferred

Prior experience in animal handling within a laboratory setting, prioritizing animal welfare

Strong problem-solving abilities, exercising independent judgment

Provide conceptual contribution into experimental design, integrated data analysis and communication of results to scientific teams and management

Experience in developing and working with neuroscience-relevant in vivo models and assays to support drug discovery programs.

Experience in primary neuron culture.

Extensive knowledge of drug delivery techniques (ICV, IT) in key CNS regions in animal model is preferred.

Extensive knowledge of brain and spinal cord anatomy.

Excellent interpersonal and communication skills and efficiency in collaborating across functional boundaries and in team environment

Experience with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.

Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.

Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.

Excellent communication and presentation skills

Biotechnology or pharmaceutical industry experience preferred but not essential.

Experience with orthotopic xenograft and humanized models of cancer.

Experience in developing and working with neuroscience-relevant in vivo models and assays to support drug discovery programs.

Extensive knowledge of drug delivery in key CNS regions in animal model is preferred.

Extensive knowledge of brain and spinal cord anatomy.

Excellent communication skills both written and oral and demonstrated efficiency in collaborating across functional boundaries.

Strong operational skills including exceptional organizational skills and performing multiple tasks simultaneously.

Experience in RNAi/gene therapy discovery is preferred but not required.