Drug Discovery Scientist Jobs in Massachusetts

Knowledge of in vivo pharmacology principles, drug metabolism and in vivo dosing and sampling skills

Demonstrated understanding and experience in performing pharmacological and mechanistic studies in in-vivo models of Retinal Diseases, including all pertinent ex-vivo analyses.

Expertise with integrated physiological assessments in the eye, including ocular dosing and dissection techniques. Experience in ocular imaging is a plus

Demonstrates good oral, written, and interpersonal skills and is a strong collaborator and team player.

Protocol development and approval in partnership with IVS and IACUC. Responsible for validity, reproducibility, interpretation, documentation.

Works under limited supervision with a high level of autonomy.

Experience and working knowledge of concepts including but not limited to in vitro pharmacology, cell biology, molecular biology, histology/immunohistochemistry, FACS, etc.

Master’s degree with 6 years of relevant industry experience

Excellent communication skills with the proven ability to build collaborative relationships and work effectively as a member of a multidisciplinary team

Continuously develops more in-depth knowledge of UCB's drug discovery process through reading, conferences and seminars

Experience with culturing a broad variety of mammalian cells; proficiency with maintenance and differentiation of iPSCs is preferred

Experience training junior researchers is a plus (CoOps, Interns)

Participate in Drug Product teams responsible for Drug Product formulation and process development for pipeline and lifecycle management projects

Experience in clinical or commercial Drug Product (or related) GMP technology transfer and validation would be a plus.

Experience working in matrix project teams with members from peer groups, CMC teams, R&D, CMOs and CROs.

Knowledge of GMP and GLP compliance

Family care benefits, including subsidized back-up care options and on-demand tutoring

Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents

Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred

Experience with RNAi is preferred

Strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment

SiRNA drug candidate screening, hit identification, and lead optimization

Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

Position will be hired based on knowledge and/or level of experience.

Exhibit a can-do attitude with excellent interpersonal and communication skills to multiple teams across different functional areas

Knowledge of molecular biology and/or immunology concepts

Experience with aseptic mammalian cell culture technique

Experience in immunoassays using techniques like flow cytometry, ELISA, homogeneous assays and microscopy

Strong attention to quality and details when exercising organizational, documentation and communication skills

Contribute to CADD technology acquisition, development, implementation and applications to pipeline projects through effective project management and cross-functional collaboration.

12+ years of drug discovery experience, working across multiple therapeutic areas including neuroscience, immunology therapeutic including project leadership roles.

Excellent knowledge in applying principles of medicinal chemistry including the design of TPDs toward drug discovery.

PhD in Chemistry, Computational Chemistry, Molecular Modeling or a related field is required with a good publication/patent track record.

Proven track record of accelerating drug discovery through application of physics-based approaches, machine learning and data analytics/science.

Make your mark for patients.

Excellent communication, organizational, and time management skills

Support the set-up, operation, and maintenance of our automated cell line management system

Additional Preferred Qualifications And Experience

Bachelor’s Degree, 2+ years of academic and / or industry experience

Requires a good understanding and practical experience in routine mammalian cell culture and microscopy

Experience with molecular biology techniques such as western blotting, immunostaining, DNA & RNA extractions, and qPCR

• Helping with various lab management needs

• Strong knowledge and hands on experience with molecular biology techniques

Responsibilities include, but are not limited to the following:

• Broad experience with mammalian cell culture (cell lines and primary cells)

• Excellent verbal and written communication skills

• Cell culture work, transfections with nucleic acids, flow cytometry

Identify, plan, and execute well defined scientific projects and communicates program strategy and timelines to management.

Knowledge in immunology or immune oncology. Understanding of cell and gene therapies.

Experience with biologics is prefered (Antibodies, ADCs, Cell therapeis etc)

Experience in molecular biology and biochemical techniques such as western blot, molecular cloning is a plus.

What Takeda Can Offer You

and Long-Term Incentive benefits. Employees are eligible to participate in

Inspire team members, provide feedback to group members and management team

Advanced knowledge of mucosal biology, lung diseases, cell/stem cell platforms

Lab experience includes many of the techniques and tools listed above

An experienced mentor who successfully fosters confidence and team commitment

2+ years of relevant postdoctoral employment experience

Preferred: 1-5 years of industry experience

Manage several projects simultaneously and act as point of accountability for in vitro display efforts on projects.

Initiate and manage external academic collaborations in the antibody discovery and engineering space.

Effectively manage projects and resources to maximize progress.

Hands-on experience with antibody phage/yeast display, HT screening, flow cytometry and kinetic analysis is required.

Experience with library construction, NGS/deep mining, multi-specific modalities, alternative antibody scaffolds and engineering is highly preferred.

Highly analytical mind, attention to detail, and organizational skills are critical.

User research knowledge and experience (1:1, focus group, etc.).

Knowledge of business design, finance, marketing, operations, or other business areas.

You seek out problems to solve and often find yourself imagining new solutions in everyday experiences.

Experience with Design Thinking/Human-centered design (IDEO methodology), UXR, or a social economics background.

Passion for product discovery with product delivery capabilities.

Experience using creative tools such as Figma or the Adobe Suite.

Lead technology transfer of core discovery capabilities into Invivyd Labs

Bring innovative expert scientific knowledge and credibility to discovery and preclinical research.

Manage a scientific team of 5-8 researchers.

Ph.D. with at least 5-8 years of pharmaceutical or biotechnology experience, preferably in antibody drug discovery and development.

Ability to design, manage and interpret outsourced non-clinical studies with collaborators, CROs including timelines and budgets.

Excellent verbal and written technical and non-technical communication skills.

Leverage and expand automated capabilities to perform suitable components of daily workflows.

Exhibit a can-do attitude with excellent interpersonal and communication skills to multiple teams across different functional areas

BS or MS in Biology or other closely related field with typically 0-3+ years of industry or academic experience

Knowledge of basic immunology concepts

Strong attention to quality and details when exercising organizational, documentation and interpersonal skills

Experience with mammalian cell culture, aseptic technique is highly desired

Leverage drug discovery experience to impact Jnana's Immunology pipeline and strategy.

Experience and success leading drug discovery programs in the biotechnology/pharmaceutical industry, ideally with an auto-immune focused target.

Lead the biological efforts on established drug discovery projects

Represent Biology team in multi-disciplinary project teams to provide robust scientific and technical support; presentation at senior leadership meetings (internal/external).

Build screening funnels to identify emerging chemical matter, and contribute to the overall research and data communication strategy for key programs.

Interrogate novel biology to drive target identification and strategic prioritization of programs.

Bachelor's Degree in a scientific discipline and 5+ years of academic / industry experience

OR Master's Degree in a scientific discipline 3+ years of academic / industry experience

OR PhD in a scientific discipline No experience required

Protein purification experience including method development, optimization, and the ability to troubleshoot standard purification protocols and instrumentation.

Experience with larger scale protein production (CMC, and tech transfer experience is a plus).

Hands on experience in the operation and control of chromatography workstations (AKTA, BioRad, etc.).

Manages the day to day materials, equipment, and other resource requirements to maintain Drug Product output.

Supports the management of external, technical interfaces to external manufacturing organizations.

Experience and well-developed understanding of process development approaches related to drug product.

Technical understanding and experience in biopharmaceutical process manufacturing operations and tech transfer to external organizations.

Strong interpersonal, organizational, and communication skills are required for this role.

Knowledge of GxP regulations and QbD principles are helpful.

Agenus is Delighted to Provide you With a Comprehensive Benefits Plan, Including Some of the Following:

Evidence of an understanding in the principles and techniques employed to characterize antibody-based cancer therapies is highly preferred.

Precise record keeping and adherence to laboratory techniques is required.

With significant independence, proactively evaluate new technologies and develop new assay for accelerating early-stage discovery activities.

Highly competitive and inclusive medical, dental and vision coverage options

Flexible Spending Accounts for medical expenses and dependent care expenses

A minimum of 3 years of relevant laboratory experience is required

In-depth understanding and experience of antibody engineering is required

Demonstrated experience working in a cross-functional organization is required

Strong written and oral communication skills are required

Experience in molecular biology techniques including bi-, multi-specifics, scFv, and/or chimeric antigen receptor (CAR) construct design and cloning is preferred

Experience in display-based technologies is preferred

Experience in project management approach to advance complex and fast-paced projects through matrixed (internal and external) teams

Perform required risk assessments, implement appropriate mitigation strategies, and document approaches through appropriate risk management systems

Manage external vendors to evaluate device technologies

Minimum of 8 years (PhD), 10 years (MS), 14 years (BS) industry experience in pulmonary and/or nasal drug delivery

Strong written and oral communication skills

Family care benefits, including subsidized back-up care options and on-demand tutoring