Scientist 3 Immunology Discovery Jobs in San Francisco, San Mateo, California

Hands-on laboratory experience in carrying out on-DNA synthesis and methodology development.

Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.

Postdoctoral or industrial work experience in the DEL field.

Experience working in the PROTAC-based drug discovery programs.

Experience working with high-throughput analytical and purification systems relevant to DEL-applications.

Excellent oral/written communication skills and creative problem-solving will be expected.

Close collaboration with an interdisciplinary team including colleagues from bioinformatics, protein & nucleic acid chemistry, clinical sciences, and biomarkers.

Independently design, implement and report in vitro and in vivo studies.

Make independent and innovative intellectual contributions to advance the program.

Interact and communicate with other groups as part of a diverse multidisciplinary team.

A PhD in immunology, molecular biology, biochemistry or related field.

● Strong organizational and effective time management skills; ability to meet tight deadlines

· Manage receipt, storage and documentation of clinical samples from Tempest-led studies

· 0-3 years of post-doctoral experience (academia or industry)

· Experience in working with human biological samples (whole blood, plasma, tissue samples) and culture techniques

· Experience in working with rodent tumor models systems

· Experience working under and writing SOPs is beneficial

Experience in automation and screening a plus.

Manage cryopreservation of tissues and cell lines.

4+ years of academic and / or industry experience

2+ years of academic and / or industry experience

3D Model Systems experience with matrix-attached models, spheroids and/or organoids

Extensive in vitro cell culture experience including establishing new cells lines with CRISPR, lenti-virus, shRNA, and inducible expression systems.

iota offers a very competitive benefits package that includes the following:

Maintains in-depth scientific knowledge in relevant therapeutic areas

Bachelor's degree with 2+ years research experience in biology, oncology, or immunology

Experience with molecular and/or cell-based assays or histopathology

Experience in independently optimizing experimental methods and assays

Experience working in interdisciplinary environments and building relationships with key external partners

5+ years of experience in cell biology and molecular biology.

Experience with T cell biology and signal transduction research.

Experience with a variety of cell-based and molecular biology assays.

Excellent problem-solving and analytical skills.

Strong written and verbal communication skills.

Experience with CAR-T cell manipulation and functional assay development.

Experience in running biochemical and immunological assays

Experience in general cell culture, functional cell-based assays, or handling primary cells

Experience with assessment of innate immune cell activation and/or antigen-specific immune response

Excellent full time benefits including comprehensive medical coverage, dental, and vision options

Perform basic tasks to support tissue culture and maintenance of immune competent cell lines

Perform experiments to characterize protein-protein interactions using PAGE, Western Blot, ELISA & SPR technologies

5+ years of relevant laboratory experience in cancer research, with a focus on small molecule drug discovery

Experience with mechanism of action studies for oncology drug discovery and validation in an industry setting

Strong understanding of the drug discovery process and demonstrated experience working on cross-functional teams

Experience with high throughput screening and hit validation techniques is a plus

Strong communication and interpersonal skills

Ph.D. in cancer biology, pharmacology, or related field

Excellent oral and written communication skills are required

Employees Are Eligible For The Following Time Off Benefits

Demonstrated ability to transform ideas into practical solutions is required

Ability to conduct laboratory experiments is required

Thorough understanding of physical and pharmaceutical chemistry principals is required

Learning agility is of high value and is required

Other work as assigned based on the project and company needs. Education and/or Experience:

Effective communication skills (oral, written, presentation, and data communication skills including but not limited to plotting using python or R).

Hands-on experience on data analysis projects, academic or industrial.

End-to-end data science project experience is a plus.

Experience working with pharmaceutical research is a plus. Physical and Other Job

Strong ability to apply scientific principles and critical thinking towards recognizing and solving pertinent problems is essential.

5+ years of academic and / or industry experience

3+ years of academic and / or industry experience

3D Model Systems experience with matrix-attached models, spheroids and/or organoids

Substantial experience in assay development and molecular biology

Attention to detail with excellent organizational and record keeping skills is a must.

Excellent oral and written communication skills, as well as the ability to effectively present scientific data

3+ years of product management experience where you collaborated with design and engineering teams

Collaborate with engineers and designers to continuously improve the product experience

Write and promote user narratives that imagine the improved experience we may want to give our customers

Natural leadership instincts and can demonstrate skills to inspire creativity

Prior experience working as a Growth PM or product marketer at a technology company

Bachelor's degree or equivalent experience

Manage CRO activities and collaborate with other functional teams to support and advance all Pheast programs

PhD. in Molecular Biology, Cancer biology, Immunology or related fields with minimum 2 years of post-doc or industry experience

Experience with various molecular biology techniques (e.g. tissue culture, gene overexpression/knock-out) is required

Experience in high-throughput screening methods and/or conducting omics-data analysis (e.g. single cell RNAseq, NGS) is highly preferred

Experience with in vivo studies is highly preferred

Experience in flow cytometry and/or working with immune cell is highly preferred

Prepare seminars, talks, lectures, and the like for dissemination of knowledge, particularly the results of projects undertaken.

A minimum of 2 - 3 years of postdoctoral research experience in advanced studies of microbiology, molecular biology, or biochemistry.

Working experience with each of the following:

Experience with complex bacterial strain construction.

Experience with writing NIH grants.

Perform research on specified topics for use in experimentation and grant writing.

Ability to manage multiple competing priorities with good planning, time management and prioritization skills

May be responsible for tracking study timelines using project management tools.

Working knowledge of clinical research regulatory requirements (e.g., GCP and ICH)

Good understanding of the principles of project planning & project management

Supporting other scientists with imaging vendors, clinical outcome assessments, biomarker sample collection and management, and external data monitoring committee.

Building analytical skills to drive operational milestones

Strong analytical skills and presentation skills as well as financial/budgetary experience

Immunology therapeutic area experience/expertise preferred

Ability to travel 80% of time

Proven ability to develop productive relationships with physicians and other healthcare professionals

Ability to develop and execute key strategies

Ability to lead, motivate, develop, and influence others

Encouragement and support will be provided to help the individual develop specialist knowledge and skill sets.

A master’s degree and 2+ years of relevant industry experience required

Masters with 5+ years of relevant industry experience is required OR PhD with 2-5 years of Post-doctoral experience is required

Previous experience with 3D organoid cultures is strongly preferred

Previous experience in regulatory T-cell (Treg) biology is strongly preferred

Strong written and oral communication skills and the ability to critically analyze data sets

Demonstrated knowledge and experience in developing and implementing technical research and development projects

Knowledge of automated, modern synthetic methods such as flow-based chemical, photochemical, and electrochemical techniques

Excellent written and oral communication skills as evidenced by a strong publication and presentation record

Excellent problem solving skills and a proactive approach to research

Advanced knowledge and proven ability to translate scientific findings into practical applications (e.g., patents)

Demonstrated strong mentoring and coaching capabilities for students, postdoctoral researchers, and young staff

Round with patients in practice to ensure Excellent Patient Experience is met. Follow-up on reported issues and assist with service recovery.

VERIFYING INSURANCE: Verifies and enters insurance information and authorization/referral requirements.

ORGANIZATION SKILLS: Organizes work to achieve maximum efficiency.

Work Department incoming referral work queue daily. Assist patients with appointments in other specialist offices as requested/referred by our physicians.

Reviews patient charts to ensure imaging is available and all pertinent information to maximize appointment.

Responsible for managing physician calendars.

Ability to manage multiple competing priorities with good planning, time management and prioritization skills

May be responsible for tracking study timelines using project management tools.

Working knowledge of clinical research regulatory requirements (e.g., GCP and ICH)

Good understanding of the principles of project planning & project management

Supporting trial leads with imaging vendors, clinical outcome assessments, biomarker sample collection and management, and external data monitoring committee.

Building analytical skills to drive operational milestones

Design and execute experiments critical for target validation and in vitro and in vivo pharmacology

Drive drug discovery efforts for Immunology

Use a wide array of techniques relevant to neuroimmunology and immunology (Flowcytometry, FACS, IHC, Spatial transcriptomics)

Design and execute experimental plans, perform rigorous analysis and interpretation of experiments

Deliver and present the experimental results to the Immunology RU and cross-functional teams.

Participate on research teams in early target discovery and work to advance programs to R&D

Experience and working knowledge of concepts including but not limited to in vitro pharmacology, cell biology, molecular biology, histology/immunohistochemistry, FACS, etc.

Master’s degree with 6 years of relevant industry experience

Excellent communication skills with the proven ability to build collaborative relationships and work effectively as a member of a multidisciplinary team

Continuously develops more in-depth knowledge of UCB's drug discovery process through reading, conferences and seminars

Experience with culturing a broad variety of mammalian cells; proficiency with maintenance and differentiation of iPSCs is preferred

Experience training junior researchers is a plus (CoOps, Interns)

Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred

Experience with RNAi is preferred

Strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment

SiRNA drug candidate screening, hit identification, and lead optimization

Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

Position will be hired based on knowledge and/or level of experience.

Exhibit a can-do attitude with excellent interpersonal and communication skills to multiple teams across different functional areas

Knowledge of molecular biology and/or immunology concepts

Experience with aseptic mammalian cell culture technique

Experience in immunoassays using techniques like flow cytometry, ELISA, homogeneous assays and microscopy

Strong attention to quality and details when exercising organizational, documentation and communication skills

Excellent communication, organizational, and time management skills

Support the set-up, operation, and maintenance of our automated cell line management system

Additional Preferred Qualifications And Experience

Bachelor’s Degree, 2+ years of academic and / or industry experience

Requires a good understanding and practical experience in routine mammalian cell culture and microscopy

Experience with molecular biology techniques such as western blotting, immunostaining, DNA & RNA extractions, and qPCR

Deep working knowledge in assay development, cell biology and signal transduction pathways in neurodegenerative diseases

Track record of project leadership, with exceptional written and verbal communication skills

10+ years Experience in drug development industry is desirable

5+ years Experience leading a cross functional team

Hiring Manager Interview (30 minutes)

Contribute as the indication expert for multiple early discovery programs related to immunology (including dermatological, gut, and neurological inflammatory diseases)

Encouragement and support will be provided to help the individual develop specialist knowledge and skill sets

You will benefit from daily interaction and collaboration with highly accomplished scientists in the field of drug discovery

Bachelor’s or Master’s degree in biology, immunology or relevant discipline. Prior industry experience is a plus

Strong work ethic, with excellent written and oral communication skills

What does the Waltham site have to offer?

You will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug projects

• Helping with various lab management needs

• Strong knowledge and hands on experience with molecular biology techniques

Responsibilities include, but are not limited to the following:

• Broad experience with mammalian cell culture (cell lines and primary cells)

• Excellent verbal and written communication skills

• Cell culture work, transfections with nucleic acids, flow cytometry

A combination of education and relevant work experience will also be considered.

Expand knowledge of complex industry analysis software to enable discovery modernization.

Maintain accurate and detailed experimental records. Ensure compliance with GSK's quality standards, safety guidelines, and regulatory requirements.

3+ years of experience in related lab experience (academic or industry).

Master's Degree preferred with 1 year experience in related lab experience.

Strong hands-on laboratory skills in immunological techniques, including ELISA, flow cytometry, and cell-based assays.

Demonstrate familiarity (work experience, Github account) with OOP concepts. Python and Java skills are a big plus.

Use business acumen and analytical skills to identify opportunities, estimate potential, and layout strategy roadmaps to solve complex business problems

Work closely with product managers to identify and answer important product questions that help improve outcomes

Communicate findings to product managers and development groups

Machine Learning and Deep Learning knowledge.

A motivated, focused, and self-starter mentality with effective communication skills, and amazing follow-through

Good organization and time management skills.

Update your knowledge of applicable industry best practices.

2 years of experience working in a Biosafety Level 2 laboratory environment.

At least 2 years of cell culture experience, preferably with human primary cells and/or stem cells.

Knowledge of statistics and using in vitro models is desirable.

Experience with immunofluorescent imaging techniques is desirable.