Senior Associate Scientist, Discovery Oncology, Organoid/3D Models

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Oncogenesis Thematic Research Center at BMS is one of the fundamental research and development engines delivering oncology therapeutics to patients. The Oncogenesis TRC has a major focus of exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Bristol Myers Squibb is a world-leader in targeted protein degradation therapeutics. We are seeking a Senior Associate Scientist to join the Oncogenesis Thematic Research Center at Bristol Myers Squibb in San Diego, CA. We are looking for a highly collaborative, passionate, and motivated biologist with broad experience in cancer biology. The candidate will be part of a growing team focused on target validation, target biology support, and development of complex tumor models (3D, matrix-attached, and/or organoid models) to enable protein degradation drug discovery efforts. We are looking for a candidate with strong technical skills in cell and molecular biology as well as clear communication skills. The ideal candidate will have experience with target identification/validation, drug discovery, and culturing patient-derived organoids.

Position Responsibilities

• Manage cryopreservation of tissues and cell lines.
• Plan and run assays to measure cell growth, apoptosis, cell cycle, and protein levels.
• Help to develop and implement 3D bioprinting of complex tumor models.
• Develop, maintain, and passage patient-derived material to enrich in-house organoid model libraries.
• Maintain accurate electronic laboratory notebooks in a timely fashion and prepare technical reports, summaries, protocols, etc.
• Collaborate with colleagues in other functional areas including translational research, informatics and chemistry to pursue target validation experiments and support drug discovery efforts.
• Experience in automation and screening a plus.
• Perform experiments to study novel oncology targets utilizing genetic and novel protein degrader-based approaches.
• Present data at internal scientific meetings.

Basic Qualifications

• Bachelor’s Degree
• 4+ years of academic and / or industry experience

Or

• Master’s Degree
• 2+ years of academic and / or industry experience

Preferred Qualifications

• 3D Model Systems experience with matrix-attached models, spheroids and/or organoids
• Extensive in vitro cell culture experience including establishing new cells lines with CRISPR, lenti-virus, shRNA, and inducible expression systems.
• Strong molecular biology experience, such as western blot, qPCR, FACS, cell cycle assays, imaging, cloning, and next-generation sequencing techniques
• Substantial experience in assay development; familiar with plate-format assays such as MSD assay, ELISA cell viability assays (e.g. CTG), apoptosis assays (e.g. Caspase), Incucyte, etc.
• Familiar with Windows, MS Office, GraphPad PRISM, FlowJo; capable of analyzing and summarizing complex data
• Excellent execution capability in a biological laboratory setting; critical thinking and problem-solving capability
• Excellent communication, presentation, collaboration, and organizational skills. Ability to handle multiple projects and work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.
• Attention to detail with excellent organizational and record keeping skills.

Other Relevant Experience

• Automation hands-on experience with cell seeders, compound printers, and other laboratory automation tools (e.g. Hamilton, Tecan instruments)
• Small molecule SAR experience
• Industry experience with protein degradation technologies or ubiquitin biology is a plus

The starting compensation for this job is a range from $79,000 to $110,000 plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

#QLR

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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