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Related keywords
- Senior Research Scientist
- Research Development Process Engineer
- Process Development Research Associate
- Clinical Research Scientist I
- Scientist Process Development
- Development Scientist I
- Process Development Scientist
- Scientist I – Protein Science
- Research Scientist Senior
- Senior Research Development Scientist
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Senior Research Scientist I; Process Development Science
Company | Curia |
Address | Hopkinton, MA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Pharmaceutical Manufacturing |
Expires | 2023-08-27 |
Posted at | 9 months ago |
Position Summary:
The senior research scientist will complete organizational and readiness tasks, and laboratory work, in the Process SciencesBusiness Unit. The senior research scientist will use research knowledge to effectively plan and manage day-to-day work cycle operations of a project; stays current with changes in applicable field. Ability to solve problems and develop new methodology, to purify a variety of biologics using classical and contemporary procedures.
Upon successful training, a senior research scientist works with minimum supervision on assigned tasks. For training and career development, later assignments may include tasks requiring greater degrees of experience, knowledge, and judgement.
Essential Duties And Responsibilities
The successful candidate will be able to work with limited guidance to plan and execute studies and be able to perform routine maintenance on instruments and equipment. Primary duties and responsibilities include:
- Lead direct reports in upstream process development.
- Identify and promptly troubleshoot technical issues.
- Keen in learning new methods and techniques.
- Provide general lab support and management.
- Communicate project updates and technical reports to supervisor and senior level management.
- Flexibility to multi-task across numerous scientific disciplines
- SME for purification of biomolecules using mammalian and/or insect systems.
- Purify biologics via pump or AKTA-based chromatography
- Perform filtration process development studies (depth filtration, UF/DF)
- Characterize samples using HPLC, UPLC, Octet and DLS.
The incumbent will be responsible for developing purification parameters to support R&D level programs and Protein manufacturing. The employee will be responsible for general lab support, executing projects within the laboratory, writing study/research plans, and summarizing data to clients and colleagues via technical reports. The position requires a drive to provide outstanding customer service by maintaining regular communications with clients, as well as meeting or exceeding quality and timeline expectations.
- Experience in protein purification along with the knowledge of AKTA systems is a must.
- Implements work plans; conducts performance reviews with the assistance of a higher-level manager. Works under only general direction. Independently determines and develops approach to solutions.
- Experience with Octet, TFF systems, HPLC/UPLC is a plus.
- Leads exchange of research information through technical assistance and instruction. Contributes to preparation of publications, reports or experimental protocols; makes presentations.
- 5 - 8 Years with BS, 3 - 6 Years with MS, 0 - 3 Years in Biochemistry, Biophysics, Biology, Chemistry, or Chemical Engineering.
- Plans work to meet personal project objectives and deadlines; assesses the needs and makes changes in process, work flow and/or assignments. Coordinates multiple, concurrent assignments on a multi-faceted research project.
- Expertise in mammalian and/or insect expression systems (Wave and bioreactor) is a plus.
- Protein purification, in the 0.01 to 100 g range, including:
- Protein characterization, including:
- Hydrophobic interaction,
- Immobilized metal affinity,
- Phase separation,
- The ability to work independently,
- Mixed mode,
- Defining critical parameters, and scale and optimize downstream processes for:
- Tangential flow and depth filtration in the 10 to 500 L range,
- Free-standing columns, AKTA™ or single-use membranes or columns,
- Manual and/or automated column packing and chromatography systems with columns having radii in 5 to 30 cm range,
- High- and ultra-high-pressure liquid chromatography,
- Size exclusion
- Chromatography and fraction collection by:
- Universal precautions,
- Protein formulation studies
- Laboratory experience, especially with:
- Affinity,
- UV/Vis spectroscopy,
- Ion exchange,
- SDS-PAGE and immunoblotting,
- Octet™,
- Biohazards and chemical hazards,
- Dynamic light scattering,
- Biohazardous and chemical wastes,
- Process and product impurity assays for: endotoxin,
- This work is performed in offices and laboratories containing office and laboratory equipment. Biological and chemical hazards are present.
- Prolonged standing for more than two hours between rest periods may be required.
- This work involves bending, stooping, kneeling, and repetitive hand motions and routinely includes the lifting and transfer of objects weighing up to 30 lbs.
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