Process Development Senior Research Associate

Garuda Therapeutics is pioneering the development of off-the-shelf hematopoietic stem cell (HSC)-based cellular therapies for treating patients with blood, bone marrow, immune, and metabolic disorders. The company uses state-of-the-art technologies in developmental biology, gene-editing, stem cells, and mechanobiology to engineer safe, compatible HSCs in scalable quantities to transform the lives of patients in need of an HSC-transplant.

The full-time role will be a key member of the process development team, focusing on scaling up pluripotent stem cell expansion and differentiation in bioreactors, as well as implementing closed-system cell processors (e.g., cell washers, magnetic separation instruments, etc.) into a clinical manufacturing process. Under the supervision of the Director of CMC Strategy and Product Development and working closely within the R&D Department, the ideal candidate will be responsible for the day-to-day execution of projects relevant to the core focus of the Garuda Tx. This position will be located in either Burlington, MA or Cambridge, MA.

Key Responsibilities Include:

• Executing well-controlled in vitro experiments to demonstrate technological feasibility and improvements for characterization of cell product and/or achieve proof-of-concept in animal models
• Culturing human pluripotent stem cells in various conditions, aiming to scale up expansion and differentiation
• Collaborating internally with Garuda team, train colleagues in new techniques and maintain relationships with external scientific partners
• Implementation of closed-system cell processing systems

Required Qualifications:

• Demonstrated excellence in executing and analyzing experiments
• Excellent organizational skills and ability to manage multiple projects
• Authorized to legally work in US
• Flexible team player excited to collaborate with internal and external partners
• Highly self-motivated and flexibility in working schedule to accommodate weekend work if necessary
• BS or MS in cell biology, engineering, or related discipline
• Experience with cell culture
• Critical thinking and independence, ability to troubleshoot, solve difficult problems, and develop process improvements
• Attention to detail and careful record-keeping
• Excellent oral and written communication skills, able to write technical reports and protocols

Preferred Qualifications:

• Experience with DOE and JMP
• 1+ years of relevant industry or academic experience
• Experience with human pluripotent stem cell culture