Senior Scientist I, Translational Immuno-Oncology Research, Precision Medicine Oncology

The Precision Medicine organization within AbbVie is committed to drive driving translational research and clinical biomarker strategy for our pre-clinical and clinical stage programs. The Translational Immuno-Oncology (I-O) group within Precision Medicine Oncology department uses advanced technologies to study cancer immunology, discover biomarkers and validate mechanisms of action of AbbVie’s innovative I-O oncology pipelines to inform clinical decisions, including biomarkers, indication/patient selection, and combinations.
We are seeking a motivated and experienced scientist with a strong scientific background in cancer immunology and a proven track record of research accomplishments on tumor immune microenvironment (TIME) to join our dynamic team. The successful candidate will work both within the Translational I-O group and as a member of cross-functional interdisciplinary teams. The candidate is expected to lead translational and biomarker research for I-O programs through internal and external collaboration.
Key Responsibilities include:

• Routinely utilize broad technical expertise in immune cell and tumor cell biology to advance translational research for both pre-clinical and clinical stage oncology projects.
• Initiate and maintain internal and external collaborations with cross-organization teams such as Discovery, biomarker, bioinformatics, pathology, DMPK, and others to ensure alignment on scientific rationale and data generation workflows.
• Independently design, execute, and analyze hypothesis-driven translational research experiments to identify pharmacodynamic (PD) biomarkers, elucidate mechanism of action, explore biomarkers of sensitivity / resistance, inform patient selection, and test novel drug-combinations to advance the AbbVie I-O pipelines.
• Effectively contribute to scientific strategies, communicate hypotheses, and present work plans and data generated to diverse audiences in both oral and written communications within a project team and/or group setting.
• Execute established methodologies and explore novel techniques within AbbVie and/or the collaboration with CROs to generate translational data that can inform clinical biomarker strategy

Basic Qualifications:

• Ability to design and develop tailored flow cytometry panels and execution of these panels on flow machines such as BD symphony and Cytek aurora is highly desirable.
• Proficiency in immune cell-based assays, molecular techniques, and strong technical skills in performing multiparameter flow cytometry and data analysis.
• BS degree with 12+ years of experience, MS degree with 10+ years of experience, or PhD degree with 4+ years of experience in cancer immunology
• Demonstrated critical thinking on how to address key questions on each project
• Ability to work independently and proactively on multiple projects in a fast-paced environment.
• Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds
• Generate reliable and reproducible data in a timely manner. Analyze, interpret, and draw conclusions independently. Generate reports and present data to the team.
• Ability to thrive in a multi-disciplinary, matrixed environment.

Preferred Qualifications:

• Hands-on experience in generating and analyzing multi-parameter gene and protein datasets is highly desirable (RNASeq, Nanostring, scRNASeq, etc.)
• Expertise in cancer immunotherapy or prior exposure to translational research/biomarker discovery
• Hands-on skill set in designing and performing complex ex-vivo experiments using fresh human tumor tissue samples such as 3D culture of immune cells and cancer cells.
• Experience working with CRO in designing and executing projects and experiments is highly desired
• Be versed in the current state of the science of the tumor microenvironment and the interplay between immune cells, stroma, and tumor cells.
• Knowledge of analytical software for routine data analysis, and exposure to AI based high throughput analysis platforms, such as OMIQ is desirable.
• Ph.D with postdoctoral research experience in cancer therapeutics targeting immune cells and epigenetics or related field in academia or pharma industry.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**
AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.