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Senior Research Associate, Analytical Development
Company | CRISPR Therapeutics |
Address | Boston, MA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-06-04 |
Posted at | 1 year ago |
Company Overview
CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.
Position Summary
Reporting into the Senior Manager, Analytical Development, in vivo, the Senior Research Associate will play a critical role in the development of chromatography-based methods, including HPLC/UPLC and CE for the CRISPR Therapeutics in vivo programs. The Senior Research Associate will be a subject matter expert in chromatography-based methods and collaborate across the in vivo program. We are seeking a driven, enthusiastic, and self-motivated individual who is comfortable working in a fast-paced environment to help develop and optimize chromatography methods. The individual will join a small, dynamic, and collaborative team of scientists.
Responsibilities
To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy
CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.
Position Summary
Reporting into the Senior Manager, Analytical Development, in vivo, the Senior Research Associate will play a critical role in the development of chromatography-based methods, including HPLC/UPLC and CE for the CRISPR Therapeutics in vivo programs. The Senior Research Associate will be a subject matter expert in chromatography-based methods and collaborate across the in vivo program. We are seeking a driven, enthusiastic, and self-motivated individual who is comfortable working in a fast-paced environment to help develop and optimize chromatography methods. The individual will join a small, dynamic, and collaborative team of scientists.
Responsibilities
- Author, review, and approve relevant test methods and tech transfer and qualification protocols and reports.
- Maintain accurate and timely records of experiments and results in the form of ELN entries.
- Support internal process development efforts via analytical testing.
- Support external troubleshooting of chromatography methods.
- Develop and optimize HPLC and capillary electrophoresis-based methods for release and stability testing of sgRNA, mRNA, and LNPs.
- Support characterization efforts for regulatory filings.
- Support investigations, OOS, and deviations related to chromatography methods.
- Support the tech transfer of chromatography methods to external labs.
- MS degree in Chemistry, Chemical Engineering, Biochemistry, Bioengineering, Pharmaceutical Sciences or related field with 3+ years of relevant experience, or BS degree in a similar field and 5+ years of relevant experience
- Experience with forced degradation studies.
- Effectively collaborate with both internal and external stakeholders.
- Excellent communication skills, technical writing, and detail oriented.
- Experience with size exclusion chromatography (SEC) and reversed phase (RP) method development.
- A minimum of five years of experience developing chromatography-based methods, including HPLC/UPLC and CE.
- Experience with SEC-MALS.
- Experience developing chromatography methods for sgRNA, mRNA, and/or LNPs.
- Experience using a fraction collector on a HPLC or UPLC.
- Experience with charged aerosol detector (CAD).
- Experience with Fragment Analyzer and/or Beckman/Sciex PA800 Plus.
- Previous experience with tech transfer and qualification.
- Collaborative – Openness, One Team
- Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
- Undaunted – Fearless, Can-do attitude
- Entrepreneurial Spirit – Proactive. Ownership mindset.
To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy
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