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Company | Generate Biomedicines |
Address | Somerville, MA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology |
Expires | 2023-06-03 |
Posted at | 1 year ago |
About Generate Biomedicines
- Learn and apply new techniques and methodologies
- Work in a small, diverse team (wetlab + computational)
- Actively contribute to the creation and execution of preclinical research programs in cell therapy
- Collaborate across the company with machine learning engineers, drug discovery researchers, and bioinformatics data scientists
- Design and build new, more effective biomedicines including cell therapies
- Serve as a leader and mentor in your field of expertise
- Closed-loop machine learning/wetlab integration
- Droplet microfluidics for molecular and cell biology
- High-throughput cell- and protein-based library generation and screening
- Protein structure prediction and determination
- Automated liquid handling and digital microfluidics
- High-throughput (HTS) library generation and screening experience desired but not required
- Familiarity with bioinformatic analyses with Python or R is strongly preferred
- Candidates with a PhD or equivalent experience will be considered
- Technical expertise in T cell engineering, including viral or nonviral genetic manipulation, is required
- Technical expertise in molecular biology, including next-generation sequencing library design and analysis, is required
- Experience in a lab automation environment preferred
- At least 2 years of relevant scientific experience, either in industry and/or as demonstrated by an academic publication record, is required
- Experience working in a team-based environment is strongly preferred
- Ability to work in a dynamic, creative and fast-paced environment required
- Strong collaboration and communication skills required
- Technical expertise in large-scale pooled screens, including massively parallel reporter assay or sort-seq experiments, is strongly preferred
- Molecular biology construct design and construction of large DNA/protein design sets
- Next-generation sequencing, especially in design and execution of novel NGS methods
- CAR-T cell discovery and characterization
- Immunological assays including multi-color flow cytometry and secreted cytokine analysis
- High-throughput, cell-based in vitro models for immuno-oncology
- Gene editing (knock out/knock in) in mammalian cell lines and primary cells
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