Associate Scientist Jobs

About CytomX Therapeutics

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engaging bispecific antibodies (“TCBs”), and immune modulators such as cytokines and checkpoint inhibitors (“CPIs”). Learn more at www.cytomx.com.

Position Summary

We seek a highly motivated Associate Scientist to support the protein engineering group. The successful candidate will contribute to development and engineering of activatable protein therapeutics spanning different modalities including cytokines, antibodies and bispecific molecules. The candidate will work on in vitro selections (phage and bacterial display library enrichment), DNA construct design and cloning, and protein binding studies.

Professional Responsibilities

• Work with project teams (internal and partnered) to design, clone, and optimize activatable protein-therapeutics.
• Use binding assays, such as ELISAs or Biolayer Interferometry to characterize activatable protein-therapeutics.
• Work with project teams (internal and partnered) to design and execute selection campaigns using phage- and bacterial-display libraries and analyze sequence data to identify scFv’s and peptides that specifically bind ‘bait’ proteins, including antibodies and cytokines.
• Prepare, analyze, and present data internally and externally.
• Collaborate closely with the interdisciplinary team to drive technological innovations related to library-screening and activatable therapeutics.

Minimum Qualifications

• MS in Biochemistry with 4+ years of experience in the biotechnology or biopharma industry OR BS in Biochemistry with 6+ years of experience in the biotechnology or biopharma industry
• Hands-on experience with in vitro selection campaigns using phage-display libraries with solution-phase and immobilized ‘bait’ proteins.
• Must have experience with ELISAs using phage-preparations.
• Must have experience with phage-library design, preparation, and routine phage techniques (including titration, amplification, microbiological sterile technique).
• Hands-on experience with routine molecular biology and cloning techniques (like DNA construct design, PCR, and ligation/recombinase-based cloning, sequence analysis and alignment).

Preferred Qualifications

• Experience with Kingfisher automation and next-generation sequencing sample preparation (NGS) for library enrichment and screening.
• Computer programming skills (e.g. Python, R, etc)
• Experience with cytokines and antibodies and their application in cancer.
• Demonstrate a commitment to CytomX values of Integrity, Commitment, Creativity, Teamwork, Accountability, and Fun
• Experience with high throughput techniques applied to phage- and bacterial-library screening.

Salary and Benefits

• The expected salary range for this role based on the primary location for this position in California is $112,000 - $125,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
• A comprehensive list oftotal reward offerings that may impact total compensation can be found on our website.

Conditions of Employment

• Background investigations are required for all positions at CytomX, consistent with applicable law.

CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)

CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.

Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [email protected].

Notice to Recruiters/Staffing Agencies

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