Senior Scientist/Associate Director Of In Vivo Pharmacology

Job Title: Senior Scientist/Associate Director of In Vivo Pharmacology
Department: R&D
Reports to: VP, Biology and Drug Discovery
Effective Date: April 4, 2023
About Acrivon Therapeutics, Inc.
Acrivon (NASDAQ: ACRV) is a clinical stage biopharmaceutical company developing precision oncology medicines that it matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing Acrivon’s proprietary proteomics-based patient responder identification platform, Acrivon Predictive Precision Proteomics, or AP3. The AP3 platform enables the creation of drug-specific proprietary OncoSignature® companion diagnostics that are used to identify the patients most likely to benefit from Acrivon’s drug candidates, referred to as patient responders. The name Acrivon (derived from Greek for “accurate”) embodies how our OncoSignature® tests link the patient’s active tumor-driving mechanisms with the drug’s mode-of-action to accurately match our therapies with patients who will benefit independent of underlying genetic tumor alterations.
Acrivon is currently advancing its lead candidate, ACR-368, a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types, which the AP3 platform predicts will have a high proportion of patient responders based on OncoSignature®-predicted sensitivity to ACR-368. In addition to ACR-368, Acrivon is also developing internally-discovered preclinical stage pipeline programs targeting critical nodes in the DNA Damage Response, or DDR, and cell cycle regulation pathways, including WEE1, a protein kinase, and PKMYT1, a closely related protein serine/threonine kinase.
Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.
Position Overview
Acrivon Therapeutics is seeking an enthusiastic and experienced Senior Scientist/Associate Director of In Vivo Pharmacology to develop and execute robust in vivo pharmacology studies, through external CROs, to support our lead discovery and clinical programs.
This position reports to VP, Biology and Drug Discovery and will be located at our US headquarters in Watertown, MA.
Duties And Responsibilities

• Leveraging CROs, deliver data to inform on: small molecule tolerability; PK, PD and efficacy relationships in CDX, PDX, and GEMM models; predictive and target engagement biomarker regulation; new target indication(s); and mechanisms to combat drug resistance.
• Contribute to authorship of documents supporting IND, clinical trials, and scientific manuscripts.
• Develop the in vivo pharmacology strategy for Acrivon’s discovery programs to enable drug candidate identification and characterization.
• Serve as pharmacology expert in cross functional discovery teams, communicating data and strategy effectively.
• Stay up to date on emerging data in disease areas.

Required Skills/Abilities

• Demonstrated ability to organize and communicate complex data sets in a clear and concise manner to cross-functional audiences.
• Demonstrated success in leading in vivo cancer pharmacology strategy and execution, with a solid foundation in cancer biology, tumor model selection, pharmacokinetics, and pharmacodynamics (biomarker selection, validation, exposure to diverse assay platforms).
• Excellent verbal and written communication and interpersonal skills to work across functions and within external collaborations.
• BS/MS with 8+ years, or Ph.D. with 5+ years of post-graduate, pharmacology experience.
• Breadth of experience across solid tumor and hematologic malignancies and a variety of experiences with molecularly targeted oncology modalities.
• Strong organizational and time-management skills.
• Desire and capacity to participate in a dynamic and fast-paced research setting.
• Prior experience working with domestic and/or international CROs.

Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.