Research Scientist - In Vivo Pharmacology

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine.
Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? Novartis is advancing cutting-edge science, starting with our proprietary gene therapy for the treatment of spinal muscular atrophy (SMA). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.
Novartis is dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product is a proprietary gene therapy approved by the US Food and Drug Administration for the treatment of pediatric patients with SMA. In addition to developing a treatment for SMA, Novartis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a Friedreich’s ataxia.
The Neuroscience Disease Area at Novartis is looking for a Research Scientist to perform tissue-based analysis in support of discovery and validation of disease relevant targets and pathways at the San Diego campus primarily focusing on gene therapies.
What you'll be doing:

• Establish protocols for behavioral studies and execute behavioral testing.
• Performs assigned tasks necessary for the husbandry and study of rodent models of disease such as animal identification by marking, breeding, and collection of tissue samples for protein, DNA, or RNA analysis.
• Work collaboratively across a dynamic scientific environment.
• Perform assigned tasks and play a role in animal studies including colony management, dosing, executing in vivo experiments under limited supervision of scientists, and tissue collection related to existing and pipeline products.
• Executes, tracks, and manages genotyping.
• Examine data and prepare technical reports, summaries, protocols, and quantitative analysis, ensuring experiments are well documented and comply with regulatory requirements. Present data to internal project teams.
• Partner with lead scientists in research and development to validate, characterize, and distribute mouse models that directly address drug discovery and program validation.
• Work interactively with research and development team to validate, characterize, and distribute mouse models that directly address drug discovery and program validation.
• Other related duties as assigned.
• Maintain and ensure safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols. Help to maintain laboratory.

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Minimum Requirements
What you'll bring to the role:

• Experience in rodent handling.
• Excellent oral and written communication skills.
• Bachelor's degree in biomedical research, neuroscience, animal behavior or animal sciences with related experience or 7 years of equivalent education/experience may be accepted.
• Preferred - Experience with transcardiac perfusion.
• Preferred - Previous industry experience.
• Preferred – Experience with survival and stereotactic surgeries.
• Preferred - Experience characterizing rodent models of various human diseases with behavioral testing.
• Experience with standard in vivo techniques in rodents, including dosing and sampling routes (e.g., po, ip, sc, iv dosing; cardiac bleeds; necropsy and organ/tumor harvest).

Why Novartis
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
The pay range for this position (Research Scientist II) at commencement of employment is expected to be between $66,000 to $99,000/ year; however, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance.
Division
Novartis Institutes for BioMedical Research
Business Unit
NEUROSCIENCE
Country
USA
Work Location
San Diego, CA
Company/Legal Entity
NIBRI
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular
Shift Work
No
Early Talent
No