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Senior Scientist/Principal Scientist, Molecular And Cellular Pharmacology
Company | Arrowhead Pharmaceuticals |
Address | San Diego, CA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Technology, Information and Internet |
Expires | 2023-09-29 |
Posted at | 8 months ago |
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
- Design and execute in vitro and in vivo studies to facilitate drug discovery and platform development in various disease areas
- Maintain a high level of productivity in the lab and perform critical experiments
- Develop, validate, and perform assays to characterize ligand-receptor interactions and to gain mechanistic understanding of drug delivery
- Present research findings to project teams and governance bodies and prepare study reports
- Guide junior scientists on the team
- Track record of guiding junior team members
- PhD in biology, bioengineering, biochemistry, or a related field with 5 to 10 years of relevant experience in biotech or pharmaceutical industry
- Expertise in developing endpoint & kinetic assays, such as luminescence & fluorescence assays, activity assays, imaging-based assays
- Strong background in characterization of ligand-receptor interactions using molecular, cellular, and biochemical approaches
- Proven scientific accomplishments including publications, conference presentations or patents
- Hands-on experience with cell culture and FACS cell sorting
- Experienced in RNA isolation, real-time PCR, RNA-seq
- Ability to adapt well to fast changing goals and research directions
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