Associate Scientist I Dmpk Jobs

In-depth knowledge and understanding of pharmacokinetic and PK/PD principles

Six plus years of experience in the pharmaceutical industry

Excellent interpersonal, written, and oral communication skills

Experience with oligonucleotide-based therapeutics, molecular biology, and genetics is preferred, or the candidate must have experience with multiple drug modalities

Partner with Research, Toxicology, and Clinical Pharmacology teams to apply model-based approaches in PK/PD/safety data integrations to inform clinical development plans

Represent DMPK on a variety of interdisciplinary teams

Contribute positively to various team by making suggestions for improvements in methods or techniques that result in benefits to the department.

Demonstrate good written and communication skills.

BS/MS & a minimum 4-5 years’ experience in the industrial food, pharmaceutical, chemical, cosmetic, consumer goods, and/or fragrance industry.

Knowledgeable in lab safety, relevant application, raw materials, & chemical processes.

Can work independently on projects without direct manager supervision.

Support technical leaders in the areas of new product development, including prototype testing, methods development, stability, and fragrance performance.

Bachelor’s degree or higher in a related field or any equivalent combination of training and experience

Two years of related experience

Master’s degree in a related field or any equivalent combination of training and experience

3-5 years’ experience in clinical or diagnostic laboratory work

Licensed Veterinary Technologist (LVT) or Medical Laboratory Technologist (MLT) or Medical Laboratory Scientist (MLS) certification

Experience implementing new molecular diagnostic tests, coordination of workflows, and demonstrated experience working as part of a team

Experience with modern data modeling and mining libraries and toolkits for Python (NumPy, SciPy, scikit-learn, pandas) or R (Bioconductor, ggplot)

Experience in generating data analytics and visualizations (Spotfire, Python dash, R Shiny, or equivalent)

Experience with database design and processing (SQL/NoSQL, RestAPI, XML, json)

Outstanding teamwork and communication skills

Hiring Manager Interview (45 minutes

Developing new data analysis and visualization tools

Must possess skills/knowledge in handling clinical specimens and be able to work in a BSL-2 environment.

We offer comprehensive package of benefits including paid time off, medical/dental/vision insurance and 401(k) to eligible employees.

Apply analytical problem-solving skills to reagent and system integration issues to identify critical performance factors.

Experience working with microorganisms involved in infectious diseases. Experience with Mycobacterium tuberculosis and Candida spp. will be a plus.

The essential requirements of the job include:

It would be a plus if you also possess previous experience in:

Strong technical product development and project management skills

Drive excellence in project management and be able to handle multiple projects

Executional excellence, personal leadership, time management and problem-solving competencies

Be able to manage multiple stakeholders and cross-functional partners

Have some knowledge of the I2M process, product specifications and cGMP

3-5 years’ relevant experience with proven track record of successful product launches and product development technology

Excellent communication skills with the ability to coordinate activities across different programs/departments

Effective troubleshooting and problem-solving skills

Excellent oral and written communication skills

PhD in Biochemistry or related field, the ideal candidate will have 2+ years in industry setting

Strong background in construct design for expression and characterization in mammalian systems

Excellent analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective

Hands on working experience in molecular biology techniques (e.g., ELISA, Western blot, PCR/qPCR, etc.)

Experience in mouse genetic models or gene therapy is a plus

Develop and characterize mouse models to support preclinical assessment of novel therapeutic molecules.

Perform routine rodent handling and dosing, including but not limited to subcutaneous, intravenous and intraperitoneal injections.

Perform bioanalytical assay and data analysis.

Compliance with all regulatory, quality, and safety requirements, including good documentation practices.

Bachelor’s degree or higher in a scientific discipline with adequate experience (MS with 1-2 yrs; BS with 2-4 yrs).

Formulation and process experience with polymer solution are desired

Performs experiments to modify and functionalize biopolymers

Demonstrates understanding in organic chemistry, polymer solutions, as well as formulation.

Demonstrates understanding of structure and property relationship of polymer solutions.

Makes strategic recommendations on data collection, integration and retention requirements, incorporating business requirements and knowledge of best practices.

Designs, develops, applies, and modifies scripts or software applications to support data management, extraction, and analysis.

Provides consultative services and is responsible to gather, analyze, present findings to leadership. TECHNICAL CAPABILITIES

Participates in multidisciplinary teams to design, develop, and recommend new approaches for data-driven decision-making.

Provides strategic direction regarding data science and AI in a specific area (e.g., cancer, surgery, planning services, marketing, healthcare delivery).

Develops analytics tools that can be used by other staff with non-technical expertise.

Excellent skills in prioritizing and time management.

Bachelor’s degree with 10 years’ experience in novel immunotherapies; or

Master’s degree with 8 years’ experience in novel immunotherapies; or

PhD with 2 years’ experience in novel immunotherapies inclusive of postdoc experience

Experience with logistical planning and overseeing the implementation of numerous simultaneous murine experiments.

Possess good interpersonal and strong written/verbal communication skills.

Typically 1-2 years of successful experience in quality processes and knowledge of quality related processes and systems

Knowledgeable of 21 CFR Part 820 regulations and ISO 13485 standard requirements

Participation in validation activities for equipment qualifications and process implementations

Well-developed written and verbal communication skills

Solid interpersonal and collaboration skills

Required skills to have for the success of this role

Working knowledge of computer software such as MSWord and skilled knowledge of Excel and/or statistical software is required

Manage direct reports and provide ongoing supervision and development opportunities

BS in science or enginerring with five (5) plus years' experience

MS with three (3) plus years’ experience

PhD with one (1) years’ experience

Demonstrated ability to manage development associate staff is required

Benefits of Working in ICON:

The Scientist will validate the quantification of Biomarkers, New Chemical and Biological Entities in tissues, biological fluids or chemical matrices.

Perform assays for routine batch analysis of Biomarkers, NCE and NBE in biological fluids/chemical matrix involving simple to complex analytical techniques.

Perform laboratory work to FDA and international regulatory GLP and GCP standards.

BS/MS and academic or industrial experience with protein purification and characterization. Candidates with a PhD may also be considered.

Experience in protein purification using ion exchange, size exclusion, affinity chromatography and other methods. Experience with FPLC systems, especially AKTA.

Background in protein science, biochemistry, bioanalytical chemistry, enzymology, or chemical biology.

Familiarity with modern analytical techniques and instrumentation for the analysis of proteins (e.g. UV/Vis, HPLC, SDS-PAGE, SEC).

Demonstrated hands-on problem solving, attention to detail, and critical thinking.

Bachelor’s Degree, or equivalent education.

Theoretical and practical knowledge to carry out job functions.

Completely follow established experimental protocols and assess results with supervision.

Recognize and report experimental variances.

Apply basic scientific principles to research.

Consult literature to understand scientific purpose of assignments. Impact projects predominantly through lab and/or pilot plant based activities.

Candidates with a PhD or equivalent experience will be considered

At least 2 years of relevant scientific experience, either in industry and/or as demonstrated by an academic publication record, is required

Experience working in a team-based environment is strongly preferred

Experience in a lab automation environment preferred

High-throughput (HTS) library generation and screening experience desired but not required

Strong collaboration and communication skills required

Knowledge and skills in designing and conducting in-vivo mouse studies and ex-vivo cell-based assays.

A driven, independent investigator with demonstrated experience in working on team projects and achieving goals in a timely manner.

Skilled in using FlowJo, GraphPad, and PowerPoint for data analysis and presentation.

Capable of interpreting and presenting data to the manager, team members, and at internal and external meetings.

Highly motivated, self-driven and focused on achieving results with critical thinking skills.

Strong problem-solving and decision-making abilities with expertise in troubleshooting experimental processes and analyzing data.

Work together with the lab manager to maintain lab stocks and order supplies; and,

Perform troubleshooting experiments within limits of knowledge and training.

Demonstrated experience in molecular biology, library preparation, next-generation sequencing approaches required;

Excellent general laboratory and organizational skills, including the ability to work independently, and to train others in laboratory techniques; and,

Assist in the development, execution and optimization of advanced new research techniques including CRISPR based genome engineering;

Prepare samples for single cell biology experiments;

Knowledge of aerosol science, experience of analytical testing and aerosol device expertise for applications of in vivo delivery

Ability to manage projects in a fast-paced environment

Strong written and oral communication skills

Family care benefits, including subsidized back-up care options and on-demand tutoring

Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents

Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options