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Senior Research Associate (Sra-Rr)
Company | BioSpace |
Address | Brisbane, CA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Internet News |
Expires | 2023-07-25 |
Posted at | 10 months ago |
Title: Senior Research Associate Manager: Associate Director, Analytical Development Department: Analytical Development Location: Brisbane, CA Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today's medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.
- Represent as subject matter expert on analytical molecular assays to support Chemistry, Manufacturing and Controls (CMC) team on new pharmaceutical products.
- Supervise 2 Research Associate Contractors.
- Handle and troubleshoot instrument issues such as on DNA sequencers and qPCR instruments.
- Evaluate new technologies and methodologies to support and advance analytical capabilities on the therapeutic products.
- Collaborate with bioinformatics department to design, develop and interpret sequencing analysis pipeline for various molecular assays including NGS assays on short-read and long-read DNA sequencing platforms.
- Troubleshoot challenging technical and experimental issues such as preparing single strand genome AAV sequence libraries on a double strand genome-based library preparation approach.
- Perform laboratory molecular techniques including NGS (next generation sequencing), nucleic acid purification such as DNA and RNA, mRNA manipulation, qPCR (quantitative polymerase chain reaction) and ddPCR (digital droplet PCR).
- Author assay development reports, method standard operating procedures (SOPs), and method transfer protocols to implement new analytical monitoring approaches on therapeutic products.
- Work closely with therapeutic program analytical lead to support as a contributing assay development author in regulatory filings with world health authority's including the FDA, EMA, and other agencies.
- Any suitable combination of education, training, or experience is acceptable.
- In the alternative, Employer will accept a Master's degree or foreign equivalent in an above-stated field of study plus two (2) years of experience in the job offered or as a Research Associate or a related position and two (2) years of experience with all of the above stated skills. Employer will accept pre- or post- Master's degree experience.
- Bachelor's degree or foreign equivalent in Molecular Biology, Biochemistry, or a related field, plus five (5) years of progressively responsible experience in the job offered, or as a Research Associate or a related position.
- Must have five (5) years of progressively responsible experience with all of the following: Working with different molecular biology techniques including NGS, genomic DNA purification, PCR, qPCR, ddPCR; Utilizing relevant hands-on laboratory experience with molecular-based assay development in an academic research laboratory or biotechnology company; Utilizing NGS data analysis pipelines and statistical analysis software; Utilizing Illumina sequencing platforms; Troubleshooting molecular techniques and evaluating data of moderate complexity; and Documenting procedures and results and keep accurate detailed records.
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