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Company | Bruker |
Address | San Jose, CA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-08-08 |
Posted at | 10 months ago |
Overview
- Assist with research projects to profile spatial genomics. Collaborate with other team members on research studies.
- Work within multidisciplinary teams at all stages of product development.
- Support the generation of test samples through cell culture and/or tissue preparation
- Support the optimization of probe chemistry and probe-based sequencing with spatial multi-omic profiling applications.
- Prepare assay reagents and other components.
- Clearly communicate and present results; contribute data for making critical design decisions.
- Analyze specimens on imaging instrumentation. Analyze research data and assist with data interpretation.
- Support the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.
- Support the development, verification and validation of product related kits and reagents.
- Prepare research reports and share findings with the team. Write protocols, develop procedures, and maintain accurate records.
- Support the optimization of sample preparation methods such as tissue/cell fixation and permeabilization.
- BS/MS in molecular biology, biochemistry, cell biology, or a related field and 5+ years of hands-on molecular biology experience in an academic or industrial setting.
- Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques. Understanding of basic absorption and emission spectroscopy.
- Experience in cell culture and tissue preparation techniques.
- Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques. Experience with microscopy.
- Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.
- Highly motivated with excellent attention to detail. Good communication (oral and written) and collaboration skills.
- Experience in troubleshooting and optimization of molecular biology assays including reagent formulation and workflow optimization.
- Experience with experimental design and data analysis. Must be capable of performing complex multi-step experiments with detailed and diligent attention to technique and protocols with accurate record keeping.
- Experience in product development including product release.
- Familiarity with basic statistical data and error analysis. Familiarity with single cell and/or spatial transcriptomics, fixation chemistry, Design of Experiments (DOE).
- Advanced fluorescence imaging techniques. Experience in microscopy image analysis.
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