Scientist, Large Molecule Research

Position Overview
The Large Molecule Research (LMR) department is seeking a highly motivated candidate to join the Biologics Characterization, Expression, and Purification (BiCEP) team. The scientist will work closely with other LMR functional groups (Protein Engineering, Antibody Discovery, Molecular Biology and Screening) as well as the therapeutic areas. The successful candidate will play a key role in the discovery of new therapeutic antibodies. The position is located in Cambridge, Massachusetts
Key Responsibilities

• Initiate, design, and perform platform improvement experiments
• Present data to department and project teams
• Provide mentoring and training to new and junior colleagues
• Express and purify recombinant antibodies, antigens, and fusion proteins to support early-stage antibody discovery research
• Perform analytics to ensure the purity, quality, and function of recombinant proteins
• Work with scientists of therapeutic teams and other departments, and maintain a culture of teamwork and collaboration in cross-functional project teams

Qualifications

• Experience with protein analytical techniques, such as HPLC, mass spectrometry, SPR (Biacore/Carterra), BLI (Octet), SDS-PAGE, ELISA, Western blotting
• Experience with transient and stable mammalian protein expression
• Strong analytical and problem-solving skills
• Demonstrated ability to independently design, execute, and present experimental results
• Excellent organizational and communication skills; ability to present findings to diverse scientific groups in clear and concise manner
• Experience in protein purification using automated (AKTA) systems
• PhD in Biochemistry, Biotechnology, Biology, Biomedical Engineering or a related field. Master’s degree with a minimum of 5 years’ relevant experience will also be considered

Preferred Qualifications

• Experience with multiple protein expression systems (i.e. yeast, bacteria, engineered cell lines), including troubleshooting difficult-to-express proteins
• Track record of scientific accomplishments as evidenced by publications/patents, including expertise in biochemistry or biophysics
• A background in biochemistry or biophysics for the generation and purification of complex antibodies and/or antigens or non-antibody formats
• Experience with protein and antigen design using sequence and structure analysis as well as purification of constructs with appropriate tags
• Expression and purification of non-standard antibodies such as bi- and tri-specific antibodies and higher valency formats

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.
According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.
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