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Scientist - Upstream Aav Process Development
Recruited by Siren Biotechnology 10 months ago
Address San Francisco, CA, United States
Scientist I/Ii, Downstream Process Development
Company | Encoded Therapeutics Inc. |
Address | South San Francisco, CA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-09-24 |
Posted at | 8 months ago |
Description
- Design, carry out, and interpret purification studies necessary to support pre-clinical development for rAAV-based gene therapies
- Provide technical expertise in purification technologies and protein chemistry, applied toward of AAV viral vectors
- Assist with group-level planning and conduct initiatives to improve workflows
- Offer guidance and lab-level leadership for incumbent associates, with possibility for 1-2 direct report(s)
- Collaborate across broader PD, AD, and MSAT departments for study, scaling, and implementation of new process technologies
- May include approximately 20% remote work, with flexibility based on project needs
- Operate chromatography (affinity, ion-exchange, multi-modal) and filtration (tangential flow, depth filtration, virus retentive) unit operations for production of preclinical rAAV drug substance
- Contribute to development of long-term PD platform strategy, including initiatives to improve process understanding, product quality, step yields, and cycle times
- Author technical reports and contribute to regulatory documents
- BS+8 / MS+6 / PhD+2 years minimum industry experience in a process development or MSAT role
- Excellent communication and presentation skills. Capability to convey complex technical information in a clear, concise, and influential manner
- Degree in a related field, including chemistry, biochemistry, chemical / biochemical engineering, or virology
- Enthusiasm for collaborative work in a dynamic environment, plus individual accountability within areas of responsibility
- Proficiency writing methods for Unicorn, and use of Empower or 32 Karat
- Prior engagement in LIMS initiatives
- Familiarity with regulatory standards for investigational therapeutics (biologics or gene therapy), which may include contributions to IND or CTA filings.
- Skilled in statistical analysis and DoE methodologies, and familiarity with JMP, MiniTab, or DesignExpert software.
- Experience with process characterization including viral clearance studies.
- Prior experience developing purification processes for virus, VLP, or gene therapy vectors for GMP clinical manufacturing.
- Working knowledge of the GMP manufacturing environment, which may include involvement in process transfer, review of batch records/deviations/CAPAs, or ‘person-in-plant’ duties.
- Fully stocked kitchen
- Team-building events
- Comprehensive benefits package, including competitive employer premium contributions
- Professional development opportunities
- Purple Tie dry cleaning service
- Meaningful stock option grants
- STD, LTD, Life and AD&D
- Generous Parental Leave program
- Pre-tax medical and dependent care programs
- PTO, sick time and holiday pay
- Fitness center
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