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R&D Scientist Jobs
Company | Generation Bio |
Address | Cambridge, MA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-09-19 |
Posted at | 8 months ago |
Generation Bio is innovating genetic medicines to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a novel DNA construct called closed-ended DNA, or ceDNA; a unique cell-targeted lipid nanoparticle delivery system, or ctLNP; and a highly scalable capsid-free manufacturing process that uses its proprietary cell-free rapid enzymatic synthesis, or RES, to produce ceDNA. The platform is designed to enable multi-year durability from a single dose, to deliver large genetic payloads, including multiple genes, to specific tissues, and to allow titration and redosing to adjust or extend expression levels in each patient. RES has the potential to expand Generation Bio’s manufacturing scale to hundreds of millions of doses to support its mission to extend the reach of genetic medicine to more people, living with more diseases, around the world.
We are a thriving, collaborative, creative community of 165 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.
Delve further. Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/
Job Location: 301 Binney Street, Suite 401, Cambridge, MA 02142 (Telecommuting is available up to one day per week)
Approximately 10% domestic and approximately 10% international travel required.
This position qualifies for Generation Bio Co.’s employee referral incentive program.
The R&D Scientists will be responsible for the following duties:
Employer requires a Master’s degree in Pharmaceutical Sciences, Biotechnology, Bioengineering, or closely related field and at least two (2) years of work experience as a Research Scientist (or related occupation) performing downstream process development in a pharmaceutical manufacturing or industrial environment.
In Addition, The Employer Requires The Following
EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
We are a thriving, collaborative, creative community of 165 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.
Delve further. Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/
Job Location: 301 Binney Street, Suite 401, Cambridge, MA 02142 (Telecommuting is available up to one day per week)
Approximately 10% domestic and approximately 10% international travel required.
This position qualifies for Generation Bio Co.’s employee referral incentive program.
The R&D Scientists will be responsible for the following duties:
- Perform in-house experiments and supervise efforts related to the purification process development;
- Provide technical resources for recent technologies in drug development;
- Prepare, analyze, and present data to cross functional teams.
- Write and review protocols, reports, and manufacturing batch records; and
- Perform testing and analysis of process intermediates and final drug substance;
- Lead tech transfer of small-scale process(es) to the MST (Manufacturing science and technology) and GMP groups for large scale manufacturing at contract manufacturing organization (CMO);
- Perform experiments and collaborate efforts related to the development of process steps including cell lysis, enzyme-based synthesis of DNA drugs, chemical precipitation, depth filtration, tangential flow filtration, sterile filtration, viral filtration, and column chromatography;
- Lead, design, and execute laboratory experiments to develop the manufacturing process for pharmaceutical substances used in gene therapy treatments;
Employer requires a Master’s degree in Pharmaceutical Sciences, Biotechnology, Bioengineering, or closely related field and at least two (2) years of work experience as a Research Scientist (or related occupation) performing downstream process development in a pharmaceutical manufacturing or industrial environment.
In Addition, The Employer Requires The Following
- Demonstrated ability optimizing scalable purification processes and manufacturing activities in a GMP environment gained through one (1) year of work experience.
- Demonstrated ability designing, executing, and troubleshooting experiments to develop downstream processes for the purification of drugs gained through two (2) years of work experience;
- Demonstrated ability testing and analyzing process intermediate and final drug substance samples gained through two (2) years of work experience;
- Demonstrated ability authoring and executing protocols, interpretating data, and generating final reports gained through two (2) years of work experience; and
EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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