Postdoc, Gene Therapy Research

Who We Are

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

What We Do

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About The Role

The postdoc in Gene Therapy research will participate in conducting preclinical stage Gene Therapy programs at Neurocrine using AAV vectors. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs.

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Your Contributions (include, But Are Not Limited To)

• Other tasks as assigned
• Be able to present data as appropriate at scientific meetings at the National and International level
• The primary role is to initiate and conduct a novel Gene Therapy research project
• Design and perform in vitro and in vivo studies in support of current and future Gene Therapy opportunities
• Prepare data summaries and present results to peers and colleagues at Neurocrine

Specific Requirements

• Knowledge about AAV vector design, capsid/cargo, serotypes, promoters, enhancers
• Experience with the application of gene therapy methods to animal experimental disease models. This includes experience with viral (preferably AAV) and/or non-viral gene delivery for upregulation of gene expression, downregulation, genome-editing or delivery of genetic material via lipid nanoparticles
• Experience or exposure to neuro-endocrinology or metabolism research will be a plus
• Ph.D. degree in biology, life sciences or related discipline, with experience in the biotech/pharmaceutical industry OR with prior non-industry postdoc experience

Requirements

• Excellent critical analysis skills
• Excellent communications, problem-solving, analytical thinking skills
• Experience with primary neurons and iPSC-derived neurons, and their use in assay development a plus
• Ability to work as part of teams
• General knowledge about the function of the central and autonomic nervous systems and gastrointestinal system
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
• Assimilates data and research findings outside of Neurocrine for application to new scientific projects
• Experience in advanced experimental technologies and their utilization in the drug discovery process
• In vivo experience working with animal models of disease
• Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas
• Excellent computer skills
• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.