Assistant Research Scientist/Engineer (Gramlich Lab) - Ophthalmology

The University of Iowa Hospitals and Clinics, Department of Ophthalmology and Visual Sciences is seeking a 100% Assistant Research Scientist (PRJ1) position in the laboratory of Dr. Oliver Gramlich. Research areas include i) modelling optic neuropathies such as glaucoma, ii) investigating the pathobiology of retinal ganglion cell degeneration and demyelination caused by Multiple Sclerosis (MS), Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and Neuromyelitis Optica (NMO), and iii) examining novel neuroprotective strategies to preserve vision and foster optic nerve remyelination in optic neuritis models. The laboratory employs rodent models of experimental autoimmune encephalomyelitis (EAE) and antibody-induced demyelination, mammalian cell culture systems and iPSC-derived organoid systems, and multidisciplinary approaches ranging from immunology to genetics and proteomics. Applicants should have solid conceptual and research backgrounds in in vivo experimentation, molecular and cellular biology, biochemistry, proteomics, and genetics with a publication record in the field of neurosciences and/or ophthalmology. Individuals who are highly motivated and willing to take risks for innovation are encouraged to apply. The successful candidate is expected to work independently, yet in a collaborative environment with a group of scientists with various levels of expertise.

University of Iowa Hospitals & Clinics—recognized as one of the best hospitals in the United States—is Iowa's only comprehensive academic medical center and a regional referral center. Each day more than 12,000 employees, students, and volunteers work together to provide safe, quality health care and excellent service for our patients. Simply stated, our mission is: Changing Medicine. Changing Lives.®

Percent of Time: 100%

Schedule: Monday - Friday, 8:00a-5:00p

Location: UIHC, Iowa City

Rotations: N/A

On Campus: This position is performed fully on campus.

Salary: $51,693 - $89,522

Pay Level: 5A

Required Qualifications

• Several years of hands-on research experience in in vivo and in vitro experimentation, molecular and cellular biology, immunology, and/or proteomics.
• Strong hand-on skills in animal experimentation (rats and mice), preferrable related to neuroscience or the visual system.
• Excellent verbal, written, and interpersonal skills.
• Proficient in standard molecular biology techniques (e.g., DNA and RNA isolation, quantitative Real Time PCR,), histological techniques (e.g. cryostat and paraffin sectioning, immunohistochemistry), common biochemical techniques (e.g., protein isolation and purification from human and mouse tissue samples, SDS-PAGE, and immunoblotting), common cell biology techniques (e.g. FACS sorting and immune cell phenotyping) and tissue culture techniques (i.e. establishing and maintaining cell lines)
• Background in neuroscience and/or ophthalmology
• A PhD or MD/PhD degree in Biological Sciences.
• Ability to independently design and conduct experiments and interpret data.

Desired Qualifications

• Prior experience with retinal imaging (e.g. optical coherence tomography), visual electrophysiology (e.g. pattern ERG, VEP recordings), and assessment of visual acuity in rodents.
• Knowledge and experience in retinal, optic nerve and CNS histology and diseases (glaucoma, MS, MOGAD, NMO).
• Hands-on skills in induction of retinal ganglion cell and/or optic nerve degeneration, surgical manipulations in the visual system, and induction of autoimmune reactions (e.g. EAE).
• Background in immunology and neuroscience is desired.
• Experience in neuron and microglia cell culture as well as in retina and brain organoid systems is a major plus.

POSITION & APPLICATION DETAILS

In Order To Be Considered For An Interview, Applicants Must Upload The Following Documents And Mark Them As a "Relevant File" To The Submission

• Cover Letter
• Resume

Job openings are posted for a minimum of 14 calendar days and may be removed from posting and filled any time after the original posting period has ended.

Successful candidates will be required to self-disclose any conviction history and will be subject to a criminal background check and credential/education verification. Up to 5 professional references will be requested at a later step in the recruitment process. This position is not eligible for University sponsorship for employment authorization.

For additional questions, please contact Melissa Monhollon, HR Manager, at [email protected] or 319-356-4674.

Posting note: This requisition is cross posted with requisition #3650. Either one (1) Assisatnt Research Scientist (PRJ1) or one (1) Postdoctoral Scholor will be hired.

Additional Information

• Schedule: Full-time
• Appointment Type: Professional and Scientific
• Classification Title: Asst Research Scientist/Engin

Compensation

• Starting Salary Minimum: 51,693.00
• Starting Salary Maximum: 89,522.00
• Pay Level: 5A

Contact Information

• Organization: Healthcare
• Contact Email: [email protected]
• Contact Name: Oliver Gramlich