Senior Research Scientist, High Content Imaging Specialist - Gene Editing And Screening (Ges) Core Facility, Memorial Sloan Kettering Cancer Center

$80,000 – $95,000

Company Overview

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. One of the world’s most respected comprehensive centers devoted exclusively to cancer, we have been recognized as one of the top two cancer hospitals in the country by U.S. News & World Report for more than 30 years.

In compliance with applicable State regulatory authorities, COVID-19 vaccination is mandatory for all MSK staff. Staff are considered fully vaccinated upon completion of a primary vaccination series for COVID-19 (i.e., one dose of a single dose vaccine or a final dose of a multi-dose vaccine series). Exceptions from the COVID-19 vaccine requirement are permitted for those who request and receive an approved medical or fully remote exemption. Requests for medical exemption can take up to two weeks to review. Vaccination or an approved medical exemption is required to start work.

Note: Individuals are eligible to receive a COVID-19 booster two months after completion of a primary vaccination series for COVID-19. Because vaccine-induced immunity can wane over time, MSK continues to strongly urge all staff to get a COVID-19 booster as soon as they become eligible to maintain their protective immunity for a longer period.

The Gene Editing and Screening (GES) Core Facility ( https://www.mskcc.org/research-advantage/core-facilities/rnai-core ) is recruiting a senior level scientist to provide high content cell- based screening (HCS) and small molecule high throughput screening (HTS) for researchers at MSKCC and outside clients . Arrayed small molecule and siRNA libraries , along with pooled functional genomics CRISPR-Cas9 and shRNA libraries, are offered for such screens. Core services include: assay development, performing large screens, data analysis, hit calling, confirmation and validation of hits, statistical calculations, dose response curves, drug and radiation synergies, synthetic lethality, and signaling pathway associations.

Responsibilities:

• Collect and enter data, assist in analyzing data , preparation of reports and manuscripts.
• Attend and participate in project meetings, assist in preparing and conducting experiments following established procedures or protocols, summarize results of experiments performed , and assist in interp reting the results of studies
• Acquire large-scale image / screening data and perform statistical data analysis
• Interact with students / other laboratory members : assist with work as directed by the PI
• Perform arrayed RNAi, CRISPR, and small molecule screening experiments in a h igh-throughput screening format
• Maintain and develop prot ocols for laboratory automation including chemical inventory
• Assist with maintaining, testing and/or implementa tion of robotics and automation
• Develop cell-based and non- cell-based assays for HCS and HTS screens

Education and experience :

• Ph.D. in cell or molecular biology or related field required
• Minimum of 3-5 years experience in running microscopy-based studies
• Extensive hands-on experience with large scale tissue culture
• Management of laboratory robotic equipment
• Experience in advanced image analysis ( i.e. ImageJ, Zen Blue, Columbus)

Technic al Knowledge and Competencies:

• Excellent verbal and written communication skills required
• Willingness to work independently and in a collaborative team environment
• Ability to work under pressure, manage competing deadlines and priorities in a fast-paced research institute environment ; respect project confidentiality
• Ability to understand and carry out instructions ; solve problems in complex situations
• Capacity to exhibit adept multi-tasking and organizational skills required
• Ability to summarize detailed issues in a concise and structured manner
• Experience with HCS and HTS assay development (biochemical/ cell-based) required
• Capacity to handle multiple tasks and competing demands under tight timeframes
• Ability to interact with all levels of staff in a professional manner
• Must demonstrate excellent interpersonal and communication skills

If you have any questions about this job opportunity, please contact:

Dr. Ralph Garippa

[email protected]

Please include a cover letter, brief statement of prior research experience and research interests, CV, and contact information for three references in your application submission.

Salary: $8 0,000 – $95 ,000

Closing

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

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