Scientist - Protein Display Technologies

Working with Us

Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Here, youll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. Youll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary

We are seeking an enthusiastic, creative, and versatile Scientist to join our collaborative Protein Engineering team to drive technological innovation, discover and engineer innovative biotherapeutic candidates. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems, develop new skills, and use them to implement robust platforms for protein therapeutic discovery. You will collaborate with talented colleagues and share what you learn. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents. Responsibilities include directed evolution and selection-based assay development using mRNA and yeast display of protein libraries, binder discovery and engineering for antibody-target interaction, and project management.

Responsibilities

• Present results internally and externally, attend industry conferences
• Some protein expression and characterization
• Analyze library NGS data using no-code or low-code bioinformatics platforms
• Directed evolution using mRNA, phage, or yeast protein display libraries
• Independently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practices
• Library design in collaboration with AI/ML engineers, library construction, NGS
• Drive efforts to discover and engineer antibodies, multispecifics, and alternative biologics formats for optimal therapeutic performance
• Independently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROs
• Accomplish goals under project team timelines

Basic Qualifications

• Bachelor's Degree in Biochemistry, Bioengineering, Molecular Biology, or related fields and 5+ years of academic / industry experience
• OR PhD No experience required
• OR Master's Degree in Biochemistry, Bioengineering, Molecular Biology, or related fields and 3+ years of academic / industry experience

Preferred Qualifications

• PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 1-3 years of relevant post-graduate or biotech/biopharma industry experience, or BS/MS with 6-8+ years of industry experience.
• Proficiency with Microsoft Office suite, FlowJo, Prism, DNA cloning software
• Demonstrated experience in working in a cross-functional organization is required
• Fundamental understanding of proteins, antibodies, and structure-function relationships required. Familiarity with protein structure analysis (Pymol, Chimera).
• Familiarity with protein-protein interaction techniques and kinetics (BLI, SPR, on-cell binding)
• Experience in lead discovery and optimization is preferred
• Bioinformatics or data science experience is desirable (bash, Python, or R)
• Excellent written and oral communication skills
• Experience and enthusiasm to work with mRNA and yeast display
• DNA and RNA purification, cloning, PCR, Sanger sequencing, NGS library preparation
• In-depth understanding and experience in antibody engineering is highly desirable
• Flow cytometry and FACS

The starting compensation for this jobis a range from $97,000 - $135,300, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final Individual Compensation Will Be Decidedbased On Demonstratedexperience.

For more on benefits, please visit our https://careers.bms.com/working-with-us.

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.