Research Associate, Next Generation Sequencing

Company Overview

GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFomeTM was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed. GC Therapeutics is based in Cambridge, MA. For additional information, please visit www.gc-tx.com.

Job Purpose

We are seeking a talented and detail-oriented individual to join our Discovery team as a research associate. Under the supervision of the Head of Discovery Platforms and senior scientists, this candidate will be responsible for the planning and execution of experiments involving next-generation sequencing (NGS) including single-cell RNA-sequencing and high-throughput library screens. This role will involve bringing a new class of cellular therapies to patients using GCTx’s Human TFomeTM platform, a synthetic biology- driven technology to differentiate human stem cells. The candidate should be coachable, determined, well- organized, responsible, and able to collaborate with other team members.

Duties and Responsibilities

General Laboratory Roles:

• Participate in the design, planning and execution of experiments.
• Follow all safe laboratory practices and company policies.
• Make observations, analyze results and maintain a detailed laboratory journal.
• Summarize results and create presentations for internal group meetings.
• Work with other members of the research team and within GCTx to accomplish company goals.

Experimental Techniques:

Molecular Biology

• Design and perform next-generation sequencing experiment including single-cell RNA-sequencing and genome sequencing, e.g. on the Illumina platform.
• Coordinate sample tracking between internal teams and submit samples to external vendors.
• Quality control, validate and troubleshoot library preparation protocols using complementary analytical methods (e.g. qPCR, ddPCR).
• Operate, maintain, quality control and troubleshoot next-generation sequencing instruments such as the Illumina MiSeq.

Qualifications

Essential Qualifications:

• Ability to work in a laboratory environment approximately 75% of the time including some weekends.
• 2+ year track record of lab experience.
• Proven experience in molecular biology laboratory techniques.
• Strong project management and organizational skills and ability to prioritize and multitask.
• Effective communication with excellent organization and interpersonal skills.
• Proven experience in molecular biology laboratory techniques.
• Experience with next-generation sequencing workflows.
• B.Sc. or M.Sc. degree in biology, cell biology, bioengineering, biochemistry, or related discipline. Preferred prior industry experience.

Additional Preferred Qualifications:

• Ability to conduct high quality presentations at internal meetings.
• Methodologies.
• Knowledge of R or Python and experience with the analysis of next-generation sequencing data.
• Authorship on scientific reports and manuscripts.
• Experience with the 10X Chromium platform for the generation of single-cell RNA-sequencing libraries and digital droplet PCR

Equal Opportunity Workplace: GC Therapeutics is an equal opportunity employer. We provide equal employment opportunities to all applicants for employment and existing employees without regard to ancestry, national origin, place of birth, race, color, gender, sexual orientation, marital status, pregnancy, religion, age, disability, gender identity, results of genetic testing, service in the military or otherwise to the full extent of all federal, state and local laws. GC Therapeutics’ equal employment opportunity policy applies to all terms and conditions of recruiting, hiring, placement, training, compensation, transfer, leave of absence, employment, promotion, layoff and termination of employment.