Director/Senior Director, Global Supply Chain And Logistics

Syros is committed to developing new standards of care for the frontline treatment of patients with hematologic malignancies. Driven by the motivation to help patients with blood disorders that have largely eluded other targeted approaches, Syros is focused on advancing a late-stage clinical pipeline, including tamibarotene, an oral selective RARα agonist in patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia with RARA gene overexpression, and SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia. For more information, visit www.syros.com and follow us on Twitter (@SyrosPharma) and LinkedIn.

Reporting to the Vice President, Chemical Pharmaceutical Development & Operations, the Director/Sr. Director, Global Supply Chain Operations will independently coordinate and lead activities for both clinical and commercial. These activities include review of study protocols, design of labels, preparation of packaging and labelling contracts, and forecasting and ordering supplies. The incumbent candidate will be responsible for coordinating the efforts of Clinical Trial Supplies Packaging with Chemical Pharmaceutical Development & Operations, Clinical Operations, Commercial, Quality Assurance, and Regulatory Affairs with the objective of establishing a plan to have clinical supplies available within the agreed time frame.

 

Responsibilities

• Manage a team of direct report(s) and consultants
• Author global supply chain and logistics related content in regulatory submissions such as INDs, NDA, IMPD, CTA, investigational brochures, clinical protocols, pharmacy manuals etc.
• Provide oversight of logistics, labeling, packaging, distribution at CROs for all clinical assets. Develop strategic plans with key stakeholders with continuous forecasting, communicating manufacturing needs
• Responsible for the Global Supply Chain and Logistics strategy, budget, planning, timelines, risk-mitigation, and forecasts for Syros clinical and upcoming commercial assets
• Responsible for establishing and overseeing Sales & Operations Planning process for commercial supplies. Work cross functionally with Chemical & Pharmaceutical Development & Operations, Quality Assurance, Clinical/Commercial, Regulatory, Finance and Legal to translate clinical/commercial demand forecast into a supply forecast for drug substance, drug product and finished goods for assigned programs/projects  
• Lead planning and implementation of commercial supply activities including secondary packaging, artwork, labeling, serialization, logistics, 3PL distribution. Collaborate with Commercial to ensure strategy, timelines, risk mitigation plans for a successful global commercial launch
• Responsible for functional SOPs, PAI readiness etc. in collaboration with Quality Assurance
• Partner with Finance on month-end inventory reconciliation, issuance of purchase orders and payment of invoices
• Provide oversight to warehousing, distribution and logistics of shipments including working with freight forwarders & brokers on import/export
• Lead inventory management / ERP implementation efforts and subsequently maintain data within ERP as it relates to supply chain and inventory management

 

 Success Factors

• Demonstrates a comprehensive understanding and knowledge of the entire Investigational Product and Commercial Supply Chain, IRT requirements, and cost drivers
• Influential in prioritizing the purchasing of supply chain products and services that do minimal damage the environment 
• Excellent team skills and demonstrates strong values
• Well-versed with regulatory requirements for INDs and NDAs and global GMPs and GCPs
• Fosters strong relationships and values collaboration to develop and execute on plans and to problem solve 
• Cost and risk conscious to ensure efficient use of transportation/supply chain resources to meet the needs of patients and customers
• Ability to act with clarity in urgent situations and to manage multiple tasks and competing priorities in a fast-paced environment 
• Flexible and responsive to the changes in the supply chain environment. Focuses on speed, cost efficiency, responsiveness, flexibility, and productivity in the production and delivery of goods  
• Excellent interpersonal, oral and written communication skills for effectively interfacing with suppliers, CMOs and internal stakeholders 
• Industry aware keeping abreast with trends, developments, and technologies within the field of supply chain, locally and internationally to understand the impact of these on Syros.  

 

 

Job Requirements

• A minimum of 10+ years of Clinical Supply / Clinical Packaging / Project Coordination experience in the pharmaceutical industry or CRO
• Ability to travel up to 10% of time
• Knowledge of cGMPs and relevant global regulations is essential

 

Finally, the candidate will need to embrace our values:

 As one team, strengthened by our diversity, we:

• Value each day of patients’ lives
• Inspire excellence in all
• Communicate transparently
• Operate with integrity and respect
• Embrace big challenges        

Finally, the candidate will need to embrace our values:

As one team, strengthened by our diversity, we:

• Value each day of patients’ lives
• Embrace big challenges
• Operate with integrity and respect
• Communicate transparently
• Inspire excellence in all

EEO Statement.

Syros Pharmaceuticals Inc. is an Equal Opportunity employer. All Syros recruiting is conducted in a fair and non-discriminatory manner without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Raise Diversity. Elevate Equity. Amplify Inclusion.

The Syros Diversity, Equity, and Inclusion (DEI) Committee invites you to envision your next role in a community where each and every one is empowered to be their best authentic self. Operating with compassion, humility, advocacy, kindness, respect, and awareness, the DEI committee meets regularly to uphold our commitment to an inclusive and welcoming workplace. We believe the unique talents, backgrounds and perspectives of each Syrosian strengthens our coordinated expression, making our company stronger and helping us to achieve our mission of developing medicines to transform patients’ lives.

We are not currently seeking third party assistance with this position.