Director/Associate Director – Early Portfolio Management

The Organization
What's happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients' quality of life using intracellular biologics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)™ platform, we are creating and advancing a diverse pipeline of oligonucleotide, enzyme, protein, and enzyme-based programs to efficiently target and engage underlying drivers of diseases.
Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular biologics.
We're a tight-knit, patient-inspired team of experts and leaders in therapeutics development and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.
The Perfect FitYou operate independently, are highly organized, and can anticipate a team's needs. You enjoy working cross functionally and do so successfully with an interpersonal acumen to build working relationships and drive collaborative initiatives. You have a strong scientific background, are naturally inquisitive, connect problems with solutions, and maintain the ability to pivot to meet changing priorities in a fast-paced environment. The Opportunity
Entrada Therapeutics is hiring a Director, Early Portfolio Management. This individual will collaborate closely with R&D to lead early-stage program planning (through clinical candidate selection) and participate as a key business partner and resource for related operational planning.
This role will be responsible for supporting the advancement of early-stage programs with an emphasis on cross-functional collaboration and driving towards portfolio-level goals. This role will also be responsible for leading the implementation of governance and stage-gate processes for the early portfolio. Reporting to the Vice President of Portfolio Management, this position will bridge Entrada’s R&D, Business, and Operation teams to drive successful development and expansion of our Portfolio.
Responsibilities
Early Portfolio Planning

• Proactively identify and raise project challenges and risks, propose contingency plans, and monitor execution of corrective actions
• Develop and maintain a real-time view of resource tracking across the early-stage portfolio to inform prioritization decisions and growth planning
• In partnership with R&D team, shepherd timely advancement of early-stage programs to value-inflection milestones by developing and maintaining project plans that include strategies, timelines, optimization of scope, risks, tradeoffs, and resource requirements
• Facilitate program meetings in collaboration with R&D team; organize high quality documents and presentations, roadmaps, deliverables, and updates as needed

Early Portfolio Governance

• Maintain view of key activities / milestones / resource needs across portfolio to support strategic planning and inform Leadership Team decision-making
• Lead the operational implementation of early-stage program evaluation and stage-gate processes in support of broader portfolio goals and milestones

Portfolio Operations

• Act as thought partner to business leads to support R&D long-range planning and annual budgeting in alignment with established portfolio milestones and corporate goals.
• Lead cross functional efforts across key pillars of Entrada’s business (e.g., R&D, Business Development/Strategy, HR, Finance, Operations, Communications) to support operational initiatives
• Support development of core capabilities that can support cross-portfolio initiatives

THE NECESSITIES
At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

• Collaboration - We are more than the sum of our parts.
• Creativity - We are creative problem solvers.
• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• Demonstrated ability to influence without authority, drive decision making, and motivate teams
• Highly motivated, goal- and results-oriented team player
• Bachelor’s degree in life sciences (graduate degree preferred), demonstrated strong scientific background, and 9 – 15 years of experience..
• Ability to adapt to changing priorities and deadlines in a highly matrixed organization
• Ability to multitask, meet deadlines, and make informed decisions
• Strong organizational, analytical, and problem-solving skills
• Strong professional written and oral communication skills
• Hands-on, “roll up your sleeves” approach toward achieving results
• Responsive and proactive, with professional maturity to readily anticipate and prioritize team needs
• Demonstrated involvement in drug discovery and /or development process
• Proficient in Microsoft Office tools
• Process-oriented yet flexible, with the aptitude to recognize which is needed
• Manages information of a highly confidential and critical nature appropriately

The Perks
By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.
Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.
Third Party Staffing Agencies
Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.