Advisor - Neuropathology Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Advisor-Neuroscience Research

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. #WeAreLilly

Responsibilities

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our Neuroscience Next Generation Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Are you looking to be part of a growing, driven team where you will help to progress new therapeutic approaches toward clinical development and commercialization? Oligonucleotide-based therapies and other novel modalities represent an existing avenue of research toward development of the next generation of therapies.

The Next Generation Therapeutics group is a newly formed team with a focus on using novel therapeutic modalities to deliver medicines for chronic pain and neurodegenerative disorders. The group, based at our Cambridge Innovation Center in Kendall Square, will work with internal and external partners to identify and deliver new novel therapies into patients at speed. The team is seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we leverage innovative RNA/oligonucleotide/gene and genomic based therapeutic modalities to enhance our portfolio.

Key Objectives/Deliverables

• Develop, validate, and perform histological protein detection assays (including antibody evaluation and characterization) and other fit-for-purpose neuropathological assays to evaluate in vivo efficacy of therapeutic agents.
• Design, execute experiments and perform data analysis, creating draft documents and presentations.
• Provide written and verbal communication of work in lab reports and team meetings.
• Lead the development, implementation, and execution of high throughput singleplex and multiplex histology assays including immunohistochemistry (IHC), immunofluorescence (IF), and RNAscope based assays.
• Troubleshoot technical challenges and provide scientific/technical input to project teams.
• Provide conceptual input into experimental design, integrated data analysis and communication of results to scientific teams and management.
• Ensure compliance with all health and safety regulations.
• Maintain an awareness of new/emerging techniques and tools relevant to the field to contribute to expanding the state-of-the-art neuropathology lab.
• Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards.
• General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment.
• Perform histological lab techniques including, but not limited to tissues grossing, processing, paraffin embedding, tissue sectioning, routine and special tissue staining, and image analysis.
• Report on-site, in the lab, 5 days a week

Minimum Qualifications

• PhD in Neuroscience, biological sciences, or related fields

Additional Skills/Preferences

• Track record of delivering neuropathology and histology-based outcomes
• Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.
• Knowledge of relevant image analysis software packages: HALO, HALO-AI, ImageScope, GraphPad Prism etc.
• Previous experience in neuroscience and/or oligonucleotide drug discovery is strongly preferred.
• Demonstrated ability to design, execute and interpret experiments independently, and to advance scientific understanding.
• Familiar with Excel, Word, PowerPoint, and analytical software associated with methods.
• Demonstrated experience in processing, organizing, analyzing, and visualizing neuropathology-based outcomes and ability to extract insight from data.
• Broad, hands-on experience in tissue sectioning (including formalin fixed paraffin embedded [FFPE] and frozen tissue sectioning), immunohistochemistry, immunofluorescence, and in situ hybridization (including multiplexed formats using automated equipment [Leica]), light microscopy and fluorescence microscopy (including Aperio slide scanners)
• Excellent interpersonal skills.
• Strong organization skills, attention to detail, critical thinking, multitasking, desire to learn new techniques and contribute to cutting-edge projects in a fast-paced working environment.
• Excellent communication skills and demonstrated efficiency in collaborating across functional boundaries.

Additional Information

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

#WeAreLilly