Associate Principal Scientist Jobs

Advanced planning, organization and time management skills including the ability to support and prioritize multiple projects

Executes on strategy, vision, and direction set by line management

Performs other tasks and assignments as needed and specified by management

Familiar knowledge of CMC and regulatory requirements, including the development of process and product specifications and writing and reviewing development reports

Expertise in laboratory operations, including budgeting, capital expense procurement and IQ/OQ, safety, and status reporting to Senior Management

Knowledge and experience with novel methods in AAV characterization (e.g. ddPCR, DLS, AUC, NGS, etc.) is preferred

Manage a team of bioconjugation scientists to meet project deliverables

A Ph.D. in Biochemistry, Chemistry, or a related discipline with 10+ years of industrial experience is preferred

Qualified BS/MS candidates should have at least 15 years of industrial experience in a drug development setting

Candidate should have experience with cGMP manufacturing, preferably in bioconjugation

Candidates with good working knowledge of analytical techniques, including HIC-, SEC-, RP-HPLC, and capillary electrophoresis, are preferred

Excellent analytical, communication, organizational, and presentation skills are essential

Work with the Consumer Science management team to prioritize workload.

To provide support to the Consumer Science management team by role modelling leadership behaviors and deputizing for line manager as required.

A qualification in food science, engineering, psychology, sociology, food technology, food chemistry or similar area

Communicating and influencing skills and working collaboratively internally and externally in an ever changing commercial and technical environment

Look for opportunities to provide informal coaching and to share experience with more junior colleagues.

Consumer science including several years managing complex programs

Mentor and/or supervise a small group of scientists to perform the above duties and to develop the above capabilities

Experience, desire, and a track record of effective mentorship of junior scientists towards timebound goals

Demonstrated experience leading cross-functional teams and driving key capability evaluations and technology selection / builds

Excellent verbal and written communication skills, demonstrated initiative, strong interpersonal and collaboration skills, and a strong desire to learn and contribute

Experience influencing regulatory strategies and a track record of supporting global filings is highly desired

What We Look For …

1+ years of relevant research experience

Extensive hands-on experience in molecular cloning and mammalian cell culture

Experience in protein analysis using Western blot and ELISA

Strong record-keeping and data documentation skills

Excellent organization and communication skills and ability to collaborate effectively

Participate in experimental design/planning and new assay development/optimization

Master’s degree with 12+ years’ of relevant experience or,

PhD in Biological Sciences, Molecular Biology, Biochemical Engineering or relevant discipline with 9+ years’ of relevant experience

Global competency with at least 3 years of experience in global big pharma or CDMO in US/EU market, mandatory

Upstream Process Development (Principal Scientist – Managerial role)

Analytical Process Development (Principal Scientist – Managerial role)

Native/fluent in spoken and written English – must be comfortable dealing with customers in US & Europe

Present data to management, cross-functional project teams, and external partners

6+ years of relevant CNS research post-PhD experience in an industry or academic setting

Experience with small molecule, gene therapy or nucleic acid therapy modalities for CNS diseases

Deep knowledge of genetic and pathophysiology of CNS diseases and relevant in vitro and animal models of diseases

Experience with advanced primary in vitro cell culture, e.g., iPSCs, Neuron Progenitor Cells (NPCs), iPSC-d Motor neurons (iMN)

Experience with transfection methods of relevant cell types (Lipofection, nucleofection, AAV transduction)

Experience or knowledge in qPCR assays, flow cytometry, calorimetry, cell culture, and viability assays.

Candidate must have strong interpersonal, communication and presentation skills and the ability to thrive in a fast-paced dynamic environment.

Good verbal and written communication skills, attention to detail and organized work habits are important.

Knowledge of aseptic handling of cells, cell culture principles, and cryopreservation.

Knowledge of cell biology, and protein structure.

Strong knowledge of protein science and cell biology.

Preferred skills include familiarity with automated chromatography hardware/software (e.g. AKTA) and previous experience culturing mammalian cells.

Inventory Management and general routine laboratory activities

Strong written and oral communication skills

Top 3 Must Have Skill Sets

Cell lysis and membrane pellet preparation

Perform batch affinity chromatography using anti-FLAG, Strep-Tactin, and Ni-NTA His affinity resin

BS in Chemistry, Biochemistry or related field and 0-3 years experience

Experience or coursework in chromatography and/or analytical chemistry

Excellent experimental design, method development, and analysis skills

Experience with Microsoft Office apps (Word, PowerPoint, Excel)

Experience with HPLC and/or UPLC chromatography systems

Experience with troubleshooting complex instrumentation

Experience with matrix management and peer to peer coaching

B.S. in Chemistry, Biochemistry, Engineering, Pharmaceuticals or related field with ten (10) years of relevant experience

M.S. in Chemistry, Biochemistry, Engineering, Pharmaceuticals or related field with seven (7) years of relevant experience

Ph.D. in Chemistry, Biochemistry, Engineering, Pharmaceuticals, or related field with three (3) years of relevant experience

Strong background and experience in separations science

Experience with complex glycan analysis and link to mechanisms of actions and various Biologic modalities (e.g., mAb, antibody-drug conjugate, fusion protein)

6+ years in an analytical role in corporate finance or management consulting with specific focus on financial planning and analysis

Lead finance support for operational projects and facilitate project proposals evaluation, periodic reporting, variance analysis and post implementation benefit analysis

Work closely with department management on the development of senior management reporting (dashboard, KPI's)

Work with and provide finance decision support to business leaders

Develop and maintain written policies and procedures applicable to the Finance Department

Bachelor's degree in Finance, Accounting, or Economics

Understands and reinforces Integral's Health and Safety Program and Quality Management Program

At least 15 years of directly relevant experience (i.e., in environmental consulting)

Pertinent certifications (e.g., DABT, BCES, CIH, Certified Senior Ecologist)

At least 5 years of experience managing technically complex projects and supervising the work of a high-functioning, multidisciplinary team

Exceptional written and oral communication skills

Generate revenue by expanding word with existing clients and developing new clients

Prepare/review data tables and reports within Laboratory Information Management System (LIMS)

Performs the above functions independently while applying basic skills to develop more specialized skills in

Participate in day-to-day operation of the Laboratory, the analysis of samples and associated duties.

Responsible for handling and processing of biological samples including competent handling and pipetting technique.

Ensure adequate levels of reference materials, control matrix, and project-specific consumables and resources are available to meet the

Assist in training personnel in the operation and maintenance of laboratory equipment including but not limited to: Liquid Scintillation

Experience with GLP and/or GMP and hands-on experience with HPLC and/or GC.

Experience with LIMS system desirable.

Familiarity and/or experience in a laboratory setting is required.

Good organizational skills; ability to follow direction and good communication skills are required.

The Ideal Candidate Would Possess

To learn more about Eurofins, please explore our website

Extensive experience with mass spectrometry technology, particularly with LCMS targeted, absolute quantitation, assay method development and LC-MS/MS interpretation

Demonstrated track record of good decision-making, attention to detail and organizational skills

Development and validation of absolute quantitative LC-MS methods for small molecule metabolites in a regulated environment in support of metabolomics-driven tests

Analysis of client samples using validated/qualified bioanalytical methodology

Develop and perform sample preparation techniques for LC-MS analysis

LC-MS operation and troubleshooting, serving as the technical expert for existing LC/MS methods

Excellent problem-solving skills and ability to work independently and collaboratively in a fast-paced research environment.

Provide scientific guidance and mentorship to junior scientists, fostering a collaborative and innovative work environment.

Strong publication record demonstrating scientific contributions in the field of cell biology and/or immunology.

5+ years of relevant laboratory experience in cancer research, with a focus on small molecule drug discovery

Experience with mechanism of action studies for oncology drug discovery and validation in an industry setting

Strong understanding of the drug discovery process and demonstrated experience working on cross-functional teams

Experience with high throughput screening and hit validation techniques is a plus

Strong communication and interpersonal skills

Ph.D. in cancer biology, pharmacology, or related field

Collaborate effectively with Biobank to ensure proper management of samples used by the molecular pathology lab.

Other Responsibilities / Detailed Duties

Optimize development of novel IHC assays in support of compound development programs.

Perform analytic validation on optimized histology assays.

Utilize digital slide scanning platform to scan whole slide images and QC metadata.

Generate data in compliance with appropriate regulations, policies and SOPs.

Leverage drug discovery experience to impact Jnana's Immunology pipeline and strategy.

Experience and success leading drug discovery programs in the biotechnology/pharmaceutical industry, ideally with an auto-immune focused target.

Lead the biological efforts on established drug discovery projects

Represent Biology team in multi-disciplinary project teams to provide robust scientific and technical support; presentation at senior leadership meetings (internal/external).

Build screening funnels to identify emerging chemical matter, and contribute to the overall research and data communication strategy for key programs.

Interrogate novel biology to drive target identification and strategic prioritization of programs.