Scientist, Computational Chemistry Jobs

Who We Are
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
What We Do
Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie
About The Role
Neurocrine is expanding our R&D chemistry capabilities, in this exciting new role you will be part of the success of the growing computational chemistry team., and will be responsible for the execution of computational-driven methodologies to help design optimized compounds with balanced properties (targets, DMPK, in-vivo) in projects,, that could range from early lead identification to late-stage optimization phase.
As a member of the multi-disciplinary drug discovery teams of medicinal chemists, DMPK, structural biologists, and pharmacologists, opportunities to impact will be abound.
Experience in one or more of the following Molecular Modeling domains is required: Protein-Ligand docking & post-docking processing, Molecular Dynamics, Homology Modeling, Quantum Chemistry, Pharmacophore Analyses, and Diversity Analyses.
Some experience with Python programming is desirable.
Knowledge about computational technologies for the assessment of early-stage targets (ex: druggability) is helpful but not essential.
Familiarity with well-known commercial molecular modeling software suites is also desirable such as Schrodinger, CCG, or Open Eye.
Responsible for the communication and presentation of computationally derived results to the discovery project teams to facilitate effective decision- making.
A collaborative & team-oriented mindset is very essential.
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Your Contributions (include, But Are Not Limited To)

• Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds
• May contribute to the assessment of early-stage projects to help determine its entry into portfolio
• Employs computational platform to make significant contribution to rationalizing experimental results, SAR evolution, and generating impactful ideas that are aligned with team’s strategy to progress compounds forward in projects
• Facilitate the medicinal chemists design new compounds with desirable optimizable properties that are predicted using cutting-edge computational technologies integrating structural, chemical and biological data
• Aligned with strategies emanating from project teams, department and computational chemistry group
• Other duties as assigned
• Conducive to sharing knowledge, practices, and work details, as needed, with teams and receptive to incorporating ideas from teams for continuous enrichment to best practices
• Plays a lead role in identifying and/or developing/refining new computational methods, in tandem with self-interest and relevance to projects, to help augment Neurocrine’s Computational Chemistry platform for Drug Discovery
• Contributes to the Computational Chemistry group’s efforts in implementing computational chemistry and/or cheminformatics methods for expediting the Design-Make-Test-Analyze discovery cycle
• Keeps abreast of developments of related interest through literature and advises project teams and/or computational chemistry group of innovation that could be harnessed into improving our platform

Requirements

• Good problem-solving, analytical thinking skills
• BS degree in Chemistry and 4+ years of relevant experience, including familiarity utilizing any or all of the following: Protein-Ligand modeling, Molecular Dynamics, Homology Modeling is preferred OR
• Good knowledge of scientific principles, methods and techniques
• Strong knowledge of scientific discipline
• Excellent communication skills with the ability to collaborate with cross-functional scientists
• Detail oriented
• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals
• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes
• Ability to meet deadlines
• Working knowledge of any or all of the following: Chemistry, Computational Chemistry, Cheminformatics, Protein Modeling, Molecular Modeling as employed for the optimization of lead compounds is preferred
• MS degree in Chemistry and 2+ years of similar experience noted above OR
• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools
• Ph.D. in Computational Chemistry or related field and 1+ years of postdoctoral experience in Structure-Based Design preferred
• Strong computer skills

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.
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The annual base salary we reasonably expect to pay is $84,100.00-$134,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.