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Principal Scientist, Medicinal Chemistry
Company | Exelixis |
Address | Radnor, PA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-09-03 |
Posted at | 9 months ago |
Company Description
- Drive medicinal chemistry projects from target validation and chemical equity identification to lead optimization and drug candidate selection, optimizing all aspects of molecular properties, including on- and off-target activities and selectivity, ADME, PK, PD, and safety profiles.
- Provide scientific leadership to medicinal chemistry team members. Mentor and coach as appropriate on SAR analysis, compound design, and synthetic route design, optimization and troubleshooting.
- Collaborate cross-functionally with biology, DMPK, and safety representatives to advance high quality compounds as drug candidates.
- Properly maintain laboratory notebooks in accordance with company policies and practices.
- Author technical documents, patent applications, and scientific manuscripts, as well as prepare and present at scientific conferences.
- Collaborate in a cross-functional team with structural biologists and computational chemists to leverage state of the art SBDD and CADD techniques to drive molecular designs.
- Comply with safe laboratory practices and EH&S guidelines. Promote a culture of safety in the laboratory.
- Present and actively participate in project and departmental research meetings.
- Direct and matrix reporting responsibilities in line with portfolio and team growth.
- Partner with CRO to direct synthetic resources to complement in-house synthesis.
- Bachelor’s degree in related discipline and a minimum of 11 years of related industrial medicinal chemistry experience; or,
- PhD in related discipline and a minimum of 5 years of related industrial medicinal chemistry experience; or,
- Master’s degree in related discipline and a minimum of 9 years of related industrial medicinal chemistry experience; or,
- Equivalent combination of education and industrial medicinal chemistry experience.
- Forging productive partnerships with key stakeholders, including computational chemistry, biology, DMPK, and toxicology in order to form productive and agile project teams.
- Experienced and knowledgeable in all aspects of drug discovery, including structure-based drug design, as well as a working understanding of related disciplines.
- Extensive synthetic organic and medicinal chemistry knowledge, including experimental techniques, theories, and best practices, including experience in multiple disease and target classes.
- Fluency working with computers including MS Word, MS PowerPoint and MS Excel required.
- Direct supervisory experience and in matrix organizations.
- Extensive experience in target compound design and synthetic pathway design.
- Demonstrated independent thought and creativity in science resulting in the delivery of optimized, high-quality drug candidates, as evidenced by peer reviewed publications and/or patent applications.
- Strong interpersonal skills, flexible, and works well within and contributes to a positive team environment.
- Able to initiate program efforts and work effectively with internal and external stakeholders.
- Excellent problem solving and SAR analysis skills.
- Extensive knowledge of drug discovery-related intellectual property matters.
- Able to apply advanced scientific and technical principles, theories, and concepts, and to contribute to the development of new principles and concepts.
- Strong organic and medicinal chemistry bench skills and ability to execute in the lab. Detailed knowledge of state-of-art synthetic chemistry techniques, purification methods, and analytical techniques.
- Comprehensive understanding of current approaches in medicinal chemistry and the ability to incorporate them into a drug discovery program.
- Able to set goals with understanding of priority and impact to program, department, and organization.
- Skilled at the effective use of scientific literature and chemical/scientific databases.
- Excellent written and verbal communication skills.
- Works on complex problem solving where analysis of situations or data requires an evaluation of intangible variables.
- As a subject matter expert, has an in-depth knowledge of medicinal chemistry and has a detailed understanding of cross functional disciplines.
- Works effectively and flexibly in a fast-paced team environment that is growing and evolving, requiring regular prioritization of projects to achieve pipeline deliverables.
- Exercises independent judgment in developing methods, techniques, and evaluation criteria to deliver results.
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