Sr. Scientist I, Protein Biochemistry

Job Posting

Sr. Scientist I, Protein Biochemistry

Sr. Scientist I, Protein Biochemistry

You will help drive drug discovery at Omeros by designing, expressing, and purifying novel biologics to support an exciting immuno-oncology program. Additionally, you will support small molecule discovery by producing protein targets for in vitro assays and high-resolution structural studies.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Who is Omeros?

Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases (e.g., complement-mediated diseases) and cancers. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is also in multiple late-stage clinical development programs focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome and COVID-19. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial. For more information about Omeros and its programs, visit www.omeros.com.

What are your job responsibilities?

• Engineer, develop and optimize the expression and purification of proteins produced in bacterial and eukaryotic expression systems Operate, maintain, and onboard new expression and purification technologies
• Mentor and oversee research efforts of associate-level scientists
• Independently execute laboratory experiments, data analysis and interpretation
• Present scientific results and attend project meetings
• Characterize proteins and using biochemical, biophysical, and structural techniques
• In collaboration with internal and external partners, evaluate and implement new technologies to enable high-resolution structure determination (e.g., X-ray crystallography, cryoEM) for early drug discovery

Experience and Education Required:

• A PhD or equivalent in Biochemistry or Biology is preferred with a minimum of 5 – 8 years of experience
• Experience with chromatographic protein purification (e.g., tag affinity chromatography, ion-exchange, size-exclusion, etc.) and the ability to develop and troubleshoot new purification approaches
• Experience with protein engineering and expression optimization, particularly in bacterial systems

Knowledge and Skills Required:

• Knowledge of the principles and practices of computer applications including word processing, spreadsheets (Excel), database management, and presentation software
• Demonstrated hands-on bench experiment troubleshooting skills
• Excellent interpersonal, written and verbal communication skills
• Demonstrated proficiency in expression, purification and stabilization of multiple different protein targets, including antibodies and antibody derivatives (e.g., Fabs, scFvs)

Behavioral Competencies Required:

• Time management skills
• Problem-solving skills
• Demonstrated ability to work in a team oriented, highly motivated environment including the ability to foster collaboration
• Demonstrated ability to present scientific results to project teams and management
• Demonstrated ability to build and maintain positive relationships with management, peers, and subordinates
• Ability to work effectively under high pressure, handling multiple priorities simultaneously

Physical Demands Required:

• Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs.
• This position requires working around hazardous materials
• May encounter prolonged periods of sitting or standing

Other Requirements:

• This position may require some work on weekends and holidays.

Compensation and Benefits:

Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for this position is $135,000 to $152,000 per year. Salaries will be determined based on knowledge, skills, education, and experience relevant to the role. Employees are offered medical, dental, vision and life insurance and a 401k plan with a company match. Employees accrue three weeks of vacation and 80 hours of sick time on an annual basis and receive ten paid holidays throughout the calendar year. This position is eligible for bonus and stock options. To learn more about Omeros, please visit www.omeros.com.

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to [email protected] or contact Omeros, asking for Human Resources, at (206) 676-5000