Senior Research Associate, High-Throughput Biologics Production

About Generate Biomedicines

Generate Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 250 employees.

The Role:

Generate Biomedicines is looking for a new colleague to join the high-throughput (HT) antibody production team within our Protein Sciences department. This cutting-edge team uses HT automated platforms and informatics tools to drive the rapid production and characterization of computationally-designed therapeutic biologics.

The individual will contribute to workflows that include HT protein expression, purification, and characterization at small-to-medium scales. They will work collaboratively within Protein Sciences to deliver purified and characterized proteins, in support of multiple programs and platforms across Generate Biomedicines. Their work will focus primarily on the production and characterization of antibodies, and occasionally on alternative therapeutic modalities.

The individual will collaborate with engineers to scale processes and methods using robotics and automation. They may also perform HT biophysical analysis methods that characterize protein biophysical properties. They will be responsible for designing experiments with the help of their supervisor, analyzing high volume datasets, communicating or presenting data and initiatives both within and outside of the team, maintaining detailed records, and generating standard operating procedures.

Here's how you will contribute:

• Detailed documentation of data on our internal LIMS systems, ELNs, and SOPs.
• Culture of mammalian cell lines and transient protein expression.
• Using protein quality control and biophysical characterization methods to assess purity, concentration, stability, non-specificity, etc. of proteins - employing a variety of analytical equipment.
• Execution and optimization of HT automated protein expression and purification workflows - using liquid handling robots, automated purification equipment, Agilent HPLC, and Cytiva AKTA systems.

The Ideal Candidate will have:

• Excellent attention to detail, documentation, and communication skills
• BSc/5+ years of experience or MSc/3+ years of experience; industry preferred
• Technical Experience with:

• Protein purification, reformulation

• Protein expression via mammalian transient transfection (eg. HEK and CHO)

• Protein characterization methodologies (eg: HPLC-aSEC, MS, CE-SDS, UV/VIS)

• Operation of liquid handling robots (eg: Hamilton, Lynx, Biomek, TECAN)

• Use of Python or another language to code scripts or process large datasets

• Deep understanding of protein expression, protein purification, and antibody characterization

Generate Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies: Generate Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate Biomedicines or its employees is strictly prohibited unless contacted directly by Generate Biomedicines's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate Biomedicines, and Generate will not owe any referral or other fees with respect thereto.

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