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Scientist / Senior Scientist, Analytical Development
Company | Third Rock Ventures |
Address | Washington DC-Baltimore Area, United States |
Employment type | FULL_TIME |
Salary | |
Category | Biotechnology Research |
Expires | 2023-08-07 |
Posted at | 1 year ago |
Role overview
Our Stealth Company is a top-tier VC-backed immunology company building on work from premier labs at Johns Hopkins. The Analytical Scientist will focus on the physiochemical characterization of protein-based immune cell engaging molecules to enable the development of effective therapies for immune-related disorders including cancer and autoimmune disease. The ideal candidate will be able to work both independently, and collaboratively with multi-disciplinary teams to prioritize product candidates for protein generation and coordinate biological characterization and validation of molecules both in vitro and in vivo. The ideal candidate will be a self-motivated, collaborative and innovative scientist with a proven ability to solve complex problems. As one of the first ten employees, you will be contributing significantly and directly to the development of therapies for patients in need.
Responsibilities
· Support research, pharmaceutical sciences, antibody development and biopharmaceuticals process development for diverse therapeutic biologics in the pipeline for early-stage product development.
Protein characterization; release and stability assays development & qualification; in-process assays in support of: cell line development, cell culture production, downstream production, formulation, fill & finish development; compatibility studies and comparability studies
· Develop and optimize analytical methods such as: invitro cell based potency assays, product identity, SEC-MALS, IEX-HPLC, HIC-HPLC, RP-HPLC, NP-HPLC, cIEF, cGE, LC-MS (intact proteins and peptides), binding kinetics, target specificity, automated media & cell testing, osmolality, residual moisture, appearance testing, oversight of visual inspection, cryo DSC, impurities (HCP, HCDNA, proteinA, and impurities) as well as other analytical methods to support protein (protein folding/structure, X-ray crystallography, cryo-EM, DSC, CD, etc.) and glycan characterization of biopharmaceutical products.
· Support testing and cross training of other team members for unit operations development which include, upstream and downstream process development.
· Assisting technology transfer of analytical methods to CDMO’s and oversight of testing performed by contractors including CDMOs.
· Contribute to the evaluation of new technology/equipment that can be applied across multiple programs.
· Document data accurately in electronic laboratory notebooks (ELN) as per established company guidelines and procedures.
· Author technical reports, procedures, protocols, and presentations for all relevant work.
· Organizational support and cross-functional project team participation.
· Present at project team and company meetings.
Qualifications
· BS or MS in Biochemistry, Biophysics, Chemical Engineering, or closely related field.
· 2+ years of experience in industrial laboratories supporting production and characterization of protein therapeutics.
· Advanced technical expertise in bioanalytical and physicochemical methodologies used to characterize protein therapeutics (as described above)
· Experience in analytical liquid chromatography in application to monoclonal antibodies and other engineered recombinant proteins in support of the responsibilities described above
· Previous experience in MALS as well as mass spectrometry-based methods will be a plus
· Working knowledge of data processing and analysis tools in Excel, FlowJo, JMP and other statistical software
· Hands on experience with method qualifications and transfers, including carbohydrate analysis and peptide map methods
· Experience with LC, MS and CE instruments handling and troubleshooting
· Ability to work efficiently in a fast-paced matrix team environment and collaborate across multiple projects simultaneously
· Strong interpersonal skills, good written and verbal communication skills.
· Familiarity with Laboratory Information Management System (LIMS) and electronic lab notebook (ELN)
We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
This is an on-site position based in the Cambridge, MA office and the employee will be required to work in the office on a regular basis.
Abata Therapeutics will require compliance with our COVID- 19 vaccination policy. Please Review our conditions of employment.
Conditions of employment:
Abata Therapeutics has implemented a mandatory vaccination policy effective Aug 12, 2021 requiring the COVID 19 vaccination for all employees. In accordance with Abata Therapeutics' duty to provide and maintain a workplace that is free of known hazards, we are adopting this policy to safeguard the health of our employees and their families, and the community at large from infectious diseases that may be reduced by vaccinations.
Individuals seeking an exemption from this requirement for medical or religious reasons should complete a request for accommodation form and submit the form to the human resources department.
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