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Scientist, Next Generation Medicine Design
Company | Bristol Myers Squibb |
Address | San Diego, CA, United States |
Employment type | TEMPORARY |
Salary | |
Category | Pharmaceutical Manufacturing |
Expires | 2023-07-13 |
Posted at | 10 months ago |
Working with Us
- In close collaboration with project teams, develop and apply a wide variety of design and computational methods to improve potency, selectivity, protein degradation profiles and ADME properties while minimizing toxicological risk and pro-actively influence decision making on project teams.
- Lead and influence the prospective use of computational methods in rigorously evaluating therapeutic targets, protein degradation modality and degrader designs within project teams.
- Significantly enhance understanding of SAR and contribute to team strategy by assimilating and interpreting data using structural modeling, AI/ML, statistical and data-mining/data-visualization technologies.
- Maintain and develop working knowledge of contemporary computational chemistry methods and their application to discovery projects.
- Pro-actively provide scholarship in early target space vis-à-vis competitive information, literature/patent reviews and mining, chemical matter feasibility assessment, target feasibility/modality assessment, druggability/binding site characterizations, as appropriate.
- Develop and apply new approaches for designing bioactive-relevant features using multi parameter optimization methods.
- Demonstrated ability to serve as a lead computational chemist on multiple discovery projects and be accountable for delivery of project goals
- Excellent communication and organizational skills and ability to work within a multidisciplinary team across geographic areas to advance discovery projects are required
- Basic programming experience in at least one scripting language (e.g., Perl, Python) or programming language (Java, C, C++)
- A working knowledge of medicinal chemistry and discovery
- Demonstrated ability to independently analyze literature and project data, formulate creative design hypotheses, data analysis and design novel agents in the context of project need.
- Personal attributes of integrity, creativity, problem solving, and strong work ethic
- Demonstrated skills in the application of computer-assisted drug design using standard modeling and computational software packages
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