Scientist Jobs

Title: Scientist

Location: Ridgefield, CT

Duration: 12+ months

Required Skills:

• Analytical chemistry
• Analytical instrumentation
• Spectroscopy
• NMR

Additional Skills

• Linux
• Very organized
• Organic chemistry

Duties

• Apply quantitative ssNMR methods to measure components of APIs and drug products.
• Present at internal scientific meetings.
• Ensure back-up and retrieval of all ssNMR data.
• Use molecular modeling and predictive tools with technologies such as solution/solid state NMR and X-ray crystallography to enable 3D structural evaluation at the atomic and molecular level.
• Apply ssNMR to characterize pharmaceutical materials such as particles, powders, and suspensions and to guide robust drug substance and drug product development.
• Apply skill in solid-state NMR (ssNMR) spectroscopy to acquire and interpret (1D and 2D 1H, 19F, 13C, 15N, etc.) data for molecular structure elucidation.
• Remain current with relevant scientific literature and apply knowledge to the design, modification and implementation of new experiments.
• Use NMR expertise to evaluate and characterize a broad range of materials, including crystalline and non-crystalline small molecule APIs, biologics, excipients, drug product intermediates, and drug products.
• Plan and perform experiments with minimal supervision to provide investigative support of structural predictions.
• Write protocols, methods and technical reports; provide scientific interpretation of results with minimal guidance.

Skills

• Excellent laboratory practices to ensure safety and sample integrity.
• Excellent oral and written communication skills, highly organized and efficient record keeping.
• Experience with solid-state NMR sample preparation, data acquisition and interpretation of multinuclear NMR data is required.
• Basic understanding of molecular structure, interatomic distances, hydrogen bonding, torsion angle strain, hydrophobic and hydrophilic interactions.
• Experience in the application and interpretation of ssNMR to study biological systems is a plus.
• Knowledgeable in the routine use of molecular modeling software (example: Gaussian, Schrodinger, Materials Studio suite, CCDC software )
• Background in use of solution NMR for structure elucidation is a plus.
• Experience with implementing and trouble-shooting ssNMR experiments.
• Experience changing Bruker ssNMR probes is required.
• Familiar with use of HPC clusters, Linux environment and associated job submission programs.
• Experience collaborating with diverse teams and demonstrated ability to work independently and with minimal supervision.
• Understands the conceptual basis behind modern computational methods such as qm-DFT, Monte Carlo methods, etc.

Education

• Ph.D. in Organic Chemistry or equivalent with 2-3 yrs. experience in the application of ssNMR Spectroscopy to structurally characterize pharmaceutically relevant small molecules.