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Senior Scientist Jobs

Company

Upkara, Inc.

Address , Ann Arbor, 48109, Mi
Employment type FULL_TIME
Salary $94,000 - $127,000 a year
Expires 2023-06-13
Posted at 1 year ago
Job Description

We are seeking a Ph.D. level researcher to join our team. The successful candidate will have expertise in the areas of protein biochemistry, protein biophysical and structural/functional characterization, analytical method development, and stability assessments.

Description

: Senior Biochemist / Chemist / Protein Biochemist

Upkara has developed a novel biopreservation technology aiming to eliminate cold storage requirements for biological reagents and pharmaceuticals. In addition to having numerous applications in the biological reagents, biobanking, and human health markets, it will also enable the delivery of life-saving medicines to regions lacking the infrastructure required for medical storage. We are currently working to commercialize this technology and are seeking a Ph.D. level researcher to join our team. The successful candidate will have expertise in the areas of protein biochemistry, protein biophysical and structural/functional characterization, analytical method development, and stability assessments. The successful candidate will also have demonstrated experience working successfully in a highly collaborative, team environment.

If you are an innovative scientist looking to join a technology company with an exciting commercial future and social impact, consider joining our team! As an Upkara Senior Scientist, you will have a vital role developing new applications for our technology in the areas of reagent, biobanking and human health and to support our continued development of the technology.

The successful candidate will be responsible for:

  • Leading cross-functional technical investigations as needed and mentoring team members at all levels with the goal of improving their technical knowledge and experimental design skills.
  • Researching new technologies and methodologies to improve our biological science and analytical capabilities and to enhance our product offerings.
  • Presenting our technology to external audiences via oral presentations, publications, and other means.
  • Working with both internal stakeholders and customers, identify new applications, design and execute proof-of-concept studies demonstrating that our technology can be used to stabilize a wide range of biological materials for a variety of applications.
  • Supervising 1-4 scientists engaged in research and development or product development activities.
  • Leveraging subject matter expertise, collaborators, and internal subject matter experts, implement appropriate analytical methods to characterize both the functional and biophysical stability of molecules stored using our technology.
  • Collaborate with the engineering team to design and test novel devices for product delivery.
  • Accurately recording and maintaining experimental data and document design changes in an organized and timely manner.
  • Enhancing our understanding of how biomolecules interact with various materials used in our biopreservation process and characterize the main degradation pathways with the goal of optimizing yield and stability.
  • Contributing to project planning and reporting on project progress regularly.


Requirements for this position include:

  • Strong analytical skills with proficiency in evaluating protein stability using techniques such as: spectrophotometric methods, cGE, Maurice, Uncle, SEC, HIC, IEX and/or RP.
  • Excellent technical writing and organizational skills.
  • Experience establishing new analytical methods.
  • Must work well in a team environment and foster collaboration.
  • Experience with word processing software and data analysis software such as EXCEL.
  • Ph.D. in biochemistry, chemistry or a related field and 2+ years of industry experience.
  • Excellent experimental design and data analysis skills.
  • Excellent problem-solving skills.


The following experience is preferred:

  • Experience designing and executing stability studies for biopharmaceuticals and/or supporting formulation development.
  • Knowledge in process development is a plus.
  • Experience evaluating the stability of biological materials including cells, viruses, proteins, and nucleic acids.
  • Previous leadership and supervisory experience.
  • Experience with cell-based assays, ELISA, PCR, fluorescence microscopy, and spectrophotometric methods is a plus.
  • Expert knowledge of protein structure analysis using modeling software, SDS PAGE analysis, Western blot, HPLC, DLS, DSF, and Mass Spectrometry.
  • Experience working in a BSL2 laboratory.
  • Experience with method validation, qualification, or verification, or experience working in a regulated laboratory.
  • Experience with quality by design (QbD) principles.
  • Experience with advanced statistical approaches including design of experiments (DOE).


EEO & Employment Eligibility:

Upkara is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Upkara also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.

As part of our commitment to the health and safety of our employees, customers and the communities in which we operate, this role requires full vaccination for COVID-19 prior to beginning work.


Salary

$94,000 - $127,000 per year