Scientist - Small Molecule X-Ray Crystallography

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The Division of Drug Product Development Materials Science & Engineering Group, at Bristol Myers Squibb is seeking a highly motivated Scientist (EG-100) with experience in small molecule, single-crystal X-ray diffraction, crystal growth, and solid form characterization of pharmaceutically relevant materials.

Responsibilities:

• Perform solid state characterization of drug substances using various analytical techniques such as PXRD, TGA, DSC, spectroscopy, PLM and DVS.
• Serve as Crystallography Representative on Materials Teams reporting on single crystal structure determination results, salt and co-crystal screens, and Crystal Structure Prediction analyses; recommend additional experiments and/or screens as appropriate.
• Use software visualization and analysis tools to assess packing arrangements, intra- and intermolecular interactions, and other structural properties affecting solubility and stability.
• Design and execute single crystal growth experiments of drug molecules to grow crystals of suitable quality from poorly crystalline materials and to help identify polymorph, salt & co-crystal form candidates.
• Provide polymorph risk assessments leveraging experimental and predicted crystal structure data.
• Determine the crystal structures of small molecule drug candidates and key intermediates; provide insights into the relationship between physicochemical properties and molecular packing and intermolecular interactions in the solid-state and how this may impact drug substance and drug product development.
• Work with Discovery chemists elucidating structures of key reaction intermediates and potential lead candidate molecules; use structural knowledge to assist chemists with drug design.

Requirements:

• Hands-on experience in single crystal X-ray diffraction, structure solution & refinement, crystallization, form selection and solid-state characterization
• Experience using structure database tools and analytical software such as the Cambridge Structural Database and related software
• Excellent interpersonal, collaboration and communications skills with a high level of technical independence and creativity
• Ph.D. in Chemistry, Materials Science, Pharmaceutical Science, or a related field with 0-3 years of relevant work experience or M.Sc. in Chemistry, Materials Science, Pharmaceutical Science, or a related field with 5-7 years of relevant work experience

Desirable skills:

• Experience with python scripting or other coding skills a plus.
• Hands on experience in crystallization/recrystallization
• Knowledge of physical and solid-state chemistry of organic molecules
• Familiarity with other solid form characterization techniques such as PXRD, TGA, DSC, and vibrational spectroscopy

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

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