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Scientist - Small Molecule X-Ray Crystallography
Company | Bristol Myers Squibb |
Address | New Brunswick, NJ, United States |
Employment type | FULL_TIME |
Salary | |
Category | Pharmaceutical Manufacturing |
Expires | 2023-06-21 |
Posted at | 1 year ago |
Working with Us
- Work with Discovery chemists elucidating structures of key reaction intermediates and potential lead candidate molecules; use structural knowledge to assist chemists with drug design.
- Perform solid state characterization of drug substances using various analytical techniques such as PXRD, TGA, DSC, spectroscopy, PLM and DVS.
- Determine the crystal structures of small molecule drug candidates and key intermediates; provide insights into the relationship between physicochemical properties and molecular packing and intermolecular interactions in the solid-state and how this may impact drug substance and drug product development.
- Design and execute single crystal growth experiments of drug molecules to grow crystals of suitable quality from poorly crystalline materials and to help identify polymorph, salt & co-crystal form candidates.
- Use software visualization and analysis tools to assess packing arrangements, intra- and intermolecular interactions, and other structural properties affecting solubility and stability.
- Serve as Crystallography Representative on Materials Teams reporting on single crystal structure determination results, salt and co-crystal screens, and Crystal Structure Prediction analyses; recommend additional experiments and/or screens as appropriate.
- Provide polymorph risk assessments leveraging experimental and predicted crystal structure data.
- Hands-on experience in single crystal X-ray diffraction, structure solution & refinement, crystallization, form selection and solid-state characterization
- Excellent interpersonal, collaboration and communications skills with a high level of technical independence and creativity
- Ph.D. in Chemistry, Materials Science, Pharmaceutical Science, or a related field with 0-3 years of relevant work experience or M.Sc. in Chemistry, Materials Science, Pharmaceutical Science, or a related field with 5-7 years of relevant work experience
- Experience using structure database tools and analytical software such as the Cambridge Structural Database and related software
- Knowledge of physical and solid-state chemistry of organic molecules
- Experience with python scripting or other coding skills a plus.
- Hands on experience in crystallization/recrystallization
- Familiarity with other solid form characterization techniques such as PXRD, TGA, DSC, and vibrational spectroscopy
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