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Scientist, Rna Biology Jobs
Company | Shape Therapeutics Inc. |
Address | Seattle, WA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Technology, Information and Internet |
Expires | 2023-10-14 |
Posted at | 7 months ago |
ShapeTX® is pioneering the field of programmable RNA medicines to repair the genetic causes of diseases. By merging innovations in AI and RNA technology to generate and analyze hundreds of billions of therapeutic possibilities, ShapeTX is developing breakthroughs in RNA editing, next-generation AAVs, and disruptive gene therapy manufacturing. The ShapeTX platform enables pharma innovators to design treatments across a wide range of diseases, including rare genetic disorders as well as debilitating conditions, such as Alzheimer's, Parkinson's, and many more. You can find us at shapetx.com and on LinkedIn and Twitter.
- Prepare written reports to support IND applications
- Maintain a detailed and up-to-date electronic laboratory notebook
- Independently plan and execute experiments to support lead candidate selection
- Create novel payload designs to improve the RNAfix technology platform
- Develop in vitro models and establish assays to identify and evaluate novel RNAfix payloads
- Collaborate with Research Therapeutics and Analytics and Informatics (A&I) teams in generating novel therapeutic payloads
- Effectively communicate cross-functionally to coordinate and support molecular assay development, reagent generation, vector optimization, and in vivo pharmacology studies
- Evaluate the biology of novel payloads using molecular based techniques
- Plan and execute rigorous and well-controlled experiments that enable data-driven decisions
- Analyze and communicate results in written and oral presentations
- Mentor junior scientists and foster collaborations with peers across the company
- Work with leadership to set program objectives and strategy
- Demonstrated scientific excellence through peer-reviewed publications or documented contributions to drug discovery project teams
- Excellent BS/MS candidates with 5-10+ years of rigorous research experience and demonstrated success within the biotech industry
- Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude
- PhD in molecular biology, cell biology, biochemistry, or other relevant scientific discipline OR
- Ability to work both independently and collaboratively in a team-science environment
- Passion for wet-lab benchwork and commitment to making data-driven decisions
- Experience with High Throughput Screening (HTS) applications
- Extensive knowledge of RNA processing and modifications, preferentially RNA splicing and ADAR-mediated RNA editing
- Experience and general understanding of current gene editing technologies
- Ability to effectively manage one's time and prioritize tasks to support multiple projects.
- Experience with in vitro and/or animal models of disease
- A collaborative, team player, and good lab citizen
- Strong background in mammalian cell culture, including transfection of cell lines
- Exquisite attention to detail, organization, and proactive communication
- Extensive knowledge of RNA structure and function and a general understanding of RNA-protein interactions
- Extensive experience and expertise with molecular biology techniques (e.g., molecular cloning, DNA/RNA purification, RT-PCR, PCR, Sanger sequencing, qPCR, ddPCR, western blotting, RNA in situ hybridization (RNA-ISH), NGS library preparation and applications
- Takes initiative with demonstrated ability to troubleshoot and think analytically
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