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Company | ELEGEN |
Address | San Carlos, CA, United States |
Employment type | FULL_TIME |
Salary | |
Category | Technology, Information and Internet |
Expires | 2023-07-20 |
Posted at | 10 months ago |
Elegen is blazing a path towards a biology-based economy with a highly innovative approach to DNA synthesis that delivers an industry leading length of 7kb in 7 business days with a 99.999% per base accuracy. Our multidisciplinary team of best-in-class biologists, chemists, hardware, and software engineers apply cutting-edge technologies and methods to solve critical bottlenecks in synthetic biology workflows to help our customers in pharma, biotech, agbio, and biomanufacturing streamline their work and realize the full potential of programmable biology.
- Develop bulk cleaning and sieving protocols for solid supports.
- Optimize the functionalization chemistry of solid supports to improve the yield and efficiency of synthesized oligonucleotides.
- Optimize cleave and deprotect workflows:
- Establish support characterization techniques such as particle analysis, scanning electron microscopy (SEM), and surface area analysis.
- Establish surface chemistry characterization methods to measure functional loading and mobility.
- Develop solid supports for our proprietary oligonucleotide synthesis hardware:
- Devise and characterize an efficient and reproducible workflow for cleaving and deprotecting protected oligos from solid supports, ensuring compatibility with downstream applications.
- Develop a set of analytical methods to characterize synthesized solid supports:
- Implement statistical analysis to ensure reliable and reproducible data interpretation.
- Specify and implement standard operating procedures and quality control (QC) procedures for manufacturing.
- Source and synthesize custom solid supports to meet the system's requirements such as surface functionalization, porosity, size distribution, sphericity, purity, and mobility.
- Strong background in polymer bead surface chemistry and functionalization.
- Proficiency in data aggregation and analysis using rigorous statistical methods.
- Strong communication skills to effectively collaborate with interdisciplinary teams and present research findings.
- PhD in synthetic organic chemistry, surface chemistry or equivalent experience.
- Proficiency in designing and executing hypothesis-driven experiments.
- In-depth knowledge of general chemistry principles, solid-phase synthesis, and instrumental analysis techniques (e.g., HPLC, LCMS, sequencing, spectrophotometry).
- Familiarity with surface analysis software and data interpretation.
- Proficiency in programming is a plus.
- Extensive experience in solid-phase oligonucleotide synthesis.
- Experience with microfluidics is a plus.
- Family and Medical Leave Act (FMLA)
- Equal Employment Opportunity (EEO)
- Employee Polygraph Protection Act (EPPA)
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