Research Associate, Process Development

Agilent inspires and supports discoveries that advance the quality of life. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables, applications and expertise. Agilent enables customers to gain the answers and insights they seek -- so they can do what they do best: improve the world around us. Information about Agilent is available at www.agilent.com.

The candidate will be responsible for process chemistry and development activities that delivers milligram to gram quantities of active pharmaceutical ingredients (API) for oligonucleotide therapeutics. This includes assisting in developing synthetic routes, methods, and techniques in preparing, separating, purifying, analyzing, quantifying, and resolving oligonucleotide process components and objectives.

Essential duties and responsibilities include but are not limited to:

• Execute process development experiments and activities. Documents analyses by completing experiment notebooks and records; implementing process chemistry applications and analyzing results of new oligonucleotide synthesis and purification methods and processes. This includes preparing process descriptions and writing technical reports to support internal technology transfer into manufacturing and preparation of client CMC submissions.
• Applies laboratory experience in chemistry and separations to issues of process optimization, scale-up and laboratory process transfer to mid and kilo scale GMP manufacturing while adhering to standard operating procedures (SOP's) and current good manufacturing practices to maintain compliance integrity (cGMP).
• Studying and implementing oligonucleotide project objectives and targets related to engineering and chemical requirements to better understand requirements. Additionally, they will be encouraged to study emerging trends in oligonucleotide analytical methods and synthesis development, review professional and technical publications, establish personal networks, and benchmark state-of-the-art practices.
• Executes Design of Experiments (DOE) and Proven Acceptable Range (PAR) experiments to support design space understanding and process validation as they relate to oligonucleotide synthesis, process chromatography, and other purification and isolation techniques.

Qualifications

• Knowledge of and skill in using computer software and hardware applications, including Microsoft products and the Internet.
• Ability to work both independently and in a team setting on a variety of projects and use individual discretion to meet required time-sensitive objectives for assigned projects.
• Bachelors, Masters, or University Degree in chemistry, chemical engineering, or science. Equivalent or a combination of education and (a minimum of 2 years) experience in a pharmaceutical environment.
• Excellent math, documentation, communication and operational troubleshooting skills. General proficiency with tools, systems, and procedures required to accomplish the job.
• Proven knowledge of oligonucleotide synthesis, purification, ultrafiltration, conjugation, and lyophilization is helpful.

Agilent Technologies, Inc. is an Equal Employment Opportunity and Affirmative Action employer. We value diversity at all levels. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to sex, pregnancy, race, religion or religious creed, color, gender, gender identity, gender expression, national origin, ancestry, physical or mental disability, medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military or veteran status, protected veteran status, or any other basis protected by federal, state, local law, ordinance, or regulation and will not be discriminated against on these bases.

Agilent Technologies, Inc., is committed to diversity in the workplace and strives to support candidates with disabilities. If you have a disability and need assistance with any part of the application or interview process or have questions about workplace accessibility, please email [email protected] or contact +1-262-754-5030.

For more information about equal employment opportunity protections, please see all of our notices for EEO below.

Pay Range

$65,120.00-$101,750.00

The salary range for this position may differ based on your actual work location.

Eligible For Company Car

No

Benefits In Brief

Travel Required

No

Schedule

Schedule:Full time

Shift

Day

Duration

No End Date

Job Function

R&D