High Content Imaging Scientist

Serna Bio is building the world’s first map of the druggable transcriptome, systematically opening up the universe of RNA biology to small molecule drug discovery. Using our Discovery Platform, we are tackling the classically intractable targets ranging from coding and non-coding RNA.
We are looking for a high content imaging scientist to work with our multidisciplinary team across multiple locations.
The Impact You’ll Make
In this role you will:

• Own analyzing data coming from existing High Content Imaging (HCI) experiments
• Review experimental designs and pilots of current HCI assays and optimize assay designs
• Lead the biological assays to validate our compounds with the CEO/CSO and Director of MedChem
• Identify and address key mechanistic questions from both a chemical and biological perspective
• Provide input on the design of the assays towards a more robust and high throughput design

The Team You’ll Join
You will be a key member on our Target Validation and Hit to Lead team, being the scientific lead on a number of projects working with our CRO partners. You will play a key role in designing, developing, and analyzing our cell-based assays, taking part in defining our drug discovery programs.
Requirements
The Experience You’ll Need
Technical Requirements

• Experience with other reporter systems (Cell Titre Glo, Luminescence, etc)
• Experience overseeing the plan, design, and implementation of major scientific initiatives and ensuring project objectives are met
• Experience in high content imaging and image analysis and HTS screens, specifically in antibody selection and immunofluorescence assay optimisation
• Experience with HCI data analysis pipelines
• PhD with 2+ years of biotech experience
• Ability to operate with a degree of independence in the design, execution of analyses and interpretation of results, including collaborating with colleagues from other teams
• In depth knowledge of software, applications, and other programs relevant to high content imaging

Interpersonal Requirements

• Excellent oral and written communication skills e.g. can tailor the complexity of communications as and when required, whilst maintaining clarity of communication.
• Ability to work under pressure, manage different projects and deliver to defined timelines
• Experience working in cross-functional and distributed teams.
• Excellent communication and attention to detail
• Experience defining roadmaps, writing detailed specifications, and on time delivery, with clear go-no-go decisions on projects

Benefits
The Values You’ll Share

• We are unapologetically unrealistic: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: our ambition grounded in relentless execution of well designed experiments.
• We are kind: We are kind to our team, their families, each other, our communities, kindness can be making time to relax, or asking the hard questions.
• We are data-driven: Data trumps opinions.
• We are one company: We operate with a ‘company first, team second’ mentality. Our success comes from working as one interdisciplinary organization.
• We are humble: We understand the limitations of our knowledge and seek to learn from others to minimize them.
• We are curious: Learning from the diverse perspectives of our fellow teammates, and from failure, is an essential part of how we make progress. At Serna Bio, we celebrate failure, mistakes, and the ability to learn from them.

What We Offer

• A place to explore the range of your interests. We pride ourselves in an environment that cultivates curiosity, creativity and autonomy. At Serna the “why” of things is always the most important question.
• The opportunity to make a difference. Your work will have a direct impact on the experiments we run, and will influence our programs destined for the clinic to affect patient outcomes.
• An environment designed to broaden your perspectives. We care deeply about inclusive working practices and diverse teams. Diversity is integral to our success, and an inclusive environment allows the team to do their best work.
• The opportunity to accelerate your career. You will have the opportunity to grow your career as we grow our labs.

About Us
Serna Bio is building the world’s first map of the druggable transcriptome, systematically opening up the universe of RNA biology to small molecule drug discovery. Using our Discovery Platform, we are tackling the classically intractable targets, with an initial focus on Oncology and Rare Disease.
The current toolkit for developing drugs is focused almost entirely on protein targets. However, 85% of the approximate 3 billion base pairs in the human genome encodes for RNA but not protein. Our platform enables a novel approach to understand RNA structure, function and binding sites in order to develop a new class of drugs. Targeting RNA in this way enables us to explore therapeutics for the many diseases with no known treatments.
Our mission is to develop a new class of drugs that will impact patient lives. We are curious, nimble, breaking new ground and growing fast. Come make an impact with us and be part of our story.