Head Of Neuro-Informatics And Clinical Biomarkers Program

The Neurological Institute is recruiting a Head of Neuroinformatics and Clinical Biomarkers for the Cleveland Clinic Brain Study (CCBS). CCBS ? the largest prospective hypercharacterized clinical study ever for brain diseases ? will collect data from thousands of neurologically healthy individuals over a 20-year period to identify brain disease biomarkers and novel targets for preventing and curing neurological disorders. The population-based longitudinal study is an enterprise-wide undertaking, enlisting Neurological Institute colleagues across Cleveland Clinic's global health system.

The study launched at Cleveland Clinic's main campus in Cleveland in January 2022 and will expand to additional Cleveland Clinic sites over time. In the study's first five years, researchers will enroll 10,000 volunteers who will be thoroughly investigated. Volunteers will be adults 50 years or older with no known neurological disorder or neurologically healthy adults age 20 or older who have a first-degree relative diagnosed with multiple sclerosis. The Neurological Institute already houses a large and exponentially growing biomarker research program, leveraging data from our patient populations with Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, and epilepsy. This experience positions the Institute well to advance the ambitious CCBS project.

The Head of Neuro-Informatics and Clinical Biomarkers program must be an accomplished researcher committed to translational molecular biomarker research in one or more neurological disorders. The candidate will leverage the CCBS data and resources and lead it in new translational directions and biomarker-based patient stratification for next-generation clinical trials. The candidate is expected to develop a cutting-edge clinical research platform that will enable our physician-scientists to jointly analyze high-dimensional OMICS and clinical data streaming from the CCBS. This platform will also allow the seamless selection of patients for personalized medicine-based clinical trials. Candidates will need a strong foundation and experience in research IT, bio-informatics and the development of physician-friendly research software platforms. In addition to this role, the candidate is expected to actively participate in a diverse translational research program ranging from data science, software development, or bioinformatics to hypercharacterize one or more neurological disorders. The successful candidate will have deep scientific knowledge and experience with genomic or other OMIC biomarker data and the combined analysis with clinical biomarkers of neurological disorders using advanced machine learning techniques. The candidate will collaborate with multiple functional teams, including research and clinical development, to ensure that the clinical biomarker strategy is effectively implemented with timely delivery of results. A track record of collaboration and teamwork is critical.

Essential Duties and Job Functions:

• Develop data quality control and analysis pipelines for genomic and other OMIC biomarkers.
• Support the leadership of the CCBS and the Neurological Institute in strategic decisions related to molecular biomarkers, IT infrastructure, and data science.
• Lead cross a functional team that includes neurologists, neurosurgeons, psychiatrists, rehabilitation clinicians, neuropsychologists, psychologists, software developers, engineers, statisticians, molecular scientists, and research coordinators responsible for discrete projects within the CCBS with focus on biomedical data science and translational science areas to improve the care of neurological disorders.
• Provide workshops for physician-scientists to teach the development of algorithms that enable data-driven care decisions.
• Collaborate with discovery and pre-clinical neuroscientists, engineers, and clinical scientists to translate clinical biomarker research into the mechanism of action studies.
• Support the execution of CCBS-based biomedical data research projects through facilitation of high-dimensional OMICS data analysis and clinical variables to test and discover surrogate or mechanistic disease biomarkers.
• Initiate large-scale research projects focusing on clinical and molecular (OMIC data) hyper characterization of neurological disorders and drive them to completion, resulting in high-quality publications, extramural funding, and clinical trials of biomarker-defined patient populations.

Qualifications

• Strong knowledge about quality control and statistical analysis of genomic or other OMIC data is required.
• Demonstrated ability to communicate effectively with basic neuroscience researchers, medicinal chemists, and patient advocacy groups.
• Experience in the discovery, characterization, and validation of innovative biomarkers that inform targets and biological pathways is required.
• Strong knowledge of modern web applications, including HTML5, CSS3, JavaScript, Java, C#, ASP.NET, .NET Core, Dash, R-Shiny or Angular, is required.
• A strong understanding of electronic healthcare record based quantitative research.
• A strong academic track record with studies focusing on leading molecular biomarkers (e.g., genomics, proteomics, etc.).
• Track record of large-scale extramural funding.
• Strong knowledge of distributed computing with high-performance computers or cloud environments using the following coding languages: Python, R, Perl, or shell scripting is required.
• A strong understanding of database development and tools, including SQL, Oracle, and Data Warehousing, is required.
• International experience is a plus.
• Advanced graduate degree (e.g., MD, MD-PhD, PhD, PharmD) required.
• Proven leadership of interdisciplinary teams consisting of data scientists, biologists, and neurologists is required.

Interested candidates, please include an up-to-date CV and cover letter with your application

Cleveland Clinic's vision is to become the best place for care and the best place to work in healthcare. We are committed to providing a safe, stable, and financially fulfilling work environment. Even in these uncertain times, Cleveland Clinic is ambitiously investing in growth. Being a physician-led organization means doing what is best for the patients, every day. Cleveland Clinic has been recognized by the American Medical Association's 2022 Joy in Medicine? Health System Recognition Program.

Cleveland Clinic is one of the world's largest and busiest health centers.Patients come to Cleveland Clinic from all over the world. We offer advanced treatment for all illnesses and disorders of the body. We enjoy a strong reputation for outstanding quality care. U.S News & World Report Hospitals ranking of 2022-2023 has named us the No. 4 hospital in the nation once again and No.1 hospital for Ohio and metro areas for Cleveland, Akron and Miami/Ft. Lauderdale. Cleveland Clinic's heart program has ranked No. 1 in the nation since 1995.

We are ranked nationally in 13 specialties, including nine in the Top 10 and six in the Top 5.

Other specialties noted for national excellence include ENT and pediatrics. Cleveland Clinic Children's offers highly specialized pediatric care in a family-centered atmosphere. It has been ranked the best children's hospital in Ohio by Child magazine.

In addition, Cleveland Clinic has been recognized as the No. 2 hospital in the world by Newsweek's World's Best Hospitals 2022 list.

Cleveland Clinic main campus and Cleveland Clinic Fairview Hospital are ranked internationally while four other locations are listed among the best hospitals nationwide -

• Cleveland Clinic FairviewsHospital
• Cleveland Clinic South Pointe Hospital
• Cleveland Clinic Hillcrest Hospital
• Cleveland Clinic Florida-Weston

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual ?America's Best Hospitals? survey. Among Cleveland Clinic's 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 21 hospitals, more than 220 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2021, there were 10.2 million total outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgical cases throughout Cleveland Clinic's health system. Patients came for treatment from every state and 185 countries.

Cleveland Clinic was named a top hospital and health system by Diversity Inc. in 2022. Companies on this list score well in talent pipeline, talent development, leadership commitment, and supplier diversity.

Cleveland Clinic values a culture where caregivers integrate diversity and inclusion throughout the enterprise. We respect and appreciate our similarities and differences; they enable us to better serve our patients, one another, and our global communities.

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